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- Live5/17/2026, 4:35:28 PM
641e0ebe1100Content snapshot
{ "scope": "vip-interneurons", "claim_text": "Basal forebrain cholinergic input modulates neocortical activity in a cell-type-specific manner: it preferentially recruits non-pyramidal interneuron subtypes (including VIP) and changes cortical state, providing the canonical framework for cholinergic disinhibition.", "raw_fields": { "n": null, "doi": "10.3389/fnsys.2012.00079", "year": "2012", "claim": "Basal forebrain cholinergic input modulates neocortical activity in a cell-type-specific manner: it preferentially recruits non-pyramidal interneuron subtypes (including VIP) and changes cortical state, providing the canonical framework for cholinergic disinhibition.", "title": "Cell-type-specific modulation of neocortical activity by basal forebrain input", "journal": "", "species": "multiple", "cite_key": "Alitto2013", "evidence": "Review of patch-clamp + in vivo recordings characterizing BF→cortex action.", "effect_size": "Different interneuron classes show distinct sensitivities to nicotinic vs. muscarinic activation.", "text_access": "fulltext", "_source_cluster": "cluster_13_neuromodulation", "replication_status": "supported", "_source_cluster_index": 19, "claim_source_sentence": "Cell-type-specific modulation of neocortical activity by basal forebrain input.", "replication_evidence_dois": [], "effect_size_source_sentence": "Cholinergic neurons of the basal forebrain target specific subsets of cortical interneurons that in turn shape cortical activity in a cell-type-specific manner." }, "section_id": "section_10", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json", "effect_size": "Different interneuron classes show distinct sensitivities to nicotinic vs. muscarinic activation.", "review_repo": "ComputationalReviewVIP", "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics", "source_kind": "review_finding", "source_path": "evidence/section_10_evidence_package.json", "source_refs": [ "paper:paper-b336c49b4f54" ], "source_span": "Cell-type-specific modulation of neocortical activity by basal forebrain input.", "study_system": null, "evidence_refs": [ { "ref": "paper:paper-b336c49b4f54" } ], "section_title": "Oscillatory Dynamics and Temporal Coordination", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }, "evidence_summary": "Review of patch-clamp + in vivo recordings characterizing BF→cortex action.", "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827", "replication_status": "supported", "review_package_ref": "analysis_bundle:ab-2ce40c33e827", "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json", "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }