Cell-type-specific markers and reporter lines have established a clear-cut mole…

Details

scope: rodent striatum, review of D1/D2 SPN segregation
claim_text: Cell-type-specific markers and reporter lines have established a clear-cut molecular, anatomical, and physiological dichotomy between D1- and D2-receptor-expressing direct- and indirect-pathway SPNs.
section_id: section_04
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
effect_size: qualitative: clear-cut dichotomy across molecular, anatomical, physiological dimensions
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-04
source_kind: review_finding
source_path: evidence/section_04_evidence_package.json
source_span: The D 1 DA receptor (Drd1a) is expressed selectively by direct pathway SPNs, whereas the D 2 (Drd2) is expressed by indirect pathway SPNs.
study_system: rodent striatum, review of D1/D2 SPN segregation
section_title: Striatal Output Pathways: Direct, Indirect, and Beyond
evidence_summary
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: replicated
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-04
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1146/annurev-neuro-061010-113641",
  "claim": "Cell-type-specific markers and reporter lines have established a clear-cut molecular, anatomical, and physiological dichotomy between D1- and D2-receptor-expressing direct- and indirect-pathway SPNs.",
  "cite_key": "Gerfen2011",
  "evidence": "",
  "effect_size": "qualitative: clear-cut dichotomy across molecular, anatomical, physiological dimensions",
  "text_access": "fulltext",
  "study_system": "rodent striatum, review of D1/D2 SPN segregation",
  "source_cluster_id": "cluster_04",
  "replication_status": "replicated",
  "claim_source_sentence": "The D 1 DA receptor (Drd1a) is expressed selectively by direct pathway SPNs, whereas the D 2 (Drd2) is expressed by indirect pathway SPNs.",
  "replication_evidence_dois": [
    "10.1038/nature09159",
    "10.1038/nature11846"
  ],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-c82c5468c0b5"
]

evidence_refs

[
  {
    "ref": "paper:paper-c82c5468c0b5"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

Cell-type-specific markers and reporter lines have established a clear-cut mole…

Details

Replication

Discussion