Version history

{
  "scope": "mouse Nav1.1-R1648H knock-in model, multiple brain regions",
  "claim_text": "The key mechanism of interneuron dysfunction in an SCN1A epilepsy mutation is a deficit of action potential initiation at the axon initial segment, not changes in somatic Na+ channels, with the deficit increasing with firing duration suggesting enhanced slow inactivation.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.0721-14.2014",
    "claim": "The key mechanism of interneuron dysfunction in an SCN1A epilepsy mutation is a deficit of action potential initiation at the axon initial segment, not changes in somatic Na+ channels, with the deficit increasing with firing duration suggesting enhanced slow inactivation.",
    "evidence": "Multisystem analysis of SCN1A R1648H knock-in mice showing ubiquitous interneuron hypoexcitability in thalamus, cortex, and hippocampus without changes in excitatory neurons.",
    "effect_size": "ubiquitous interneuron hypoexcitability across thalamus, cortex, hippocampus; no changes in excitatory neurons",
    "text_access": "abstract_only",
    "study_system": "mouse Nav1.1-R1648H knock-in model, multiple brain regions",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Instead, the key mechanism of interneuron dysfunction was a deficit of action potential initiation at the axon initial segment that was identified by analyzing action potential firing. This deficit increased with the duration of firing periods.",
    "replication_evidence_dois": [
      "10.1073/pnas.1411131111"
    ],
    "effect_size_source_sentence": "We found a ubiquitous hypoexcitability of interneurons in thalamus, cortex, and hippocampus, without detectable changes in excitatory neurons."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "ubiquitous interneuron hypoexcitability across thalamus, cortex, hippocampus; no changes in excitatory neurons",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-7a06f96aaed3"
  ],
  "source_span": "Instead, the key mechanism of interneuron dysfunction was a deficit of action potential initiation at the axon initial segment that was identified by analyzing action potential firing. This deficit increased with the duration of firing periods.",
  "study_system": "mouse Nav1.1-R1648H knock-in model, multiple brain regions",
  "evidence_refs": [
    {
      "ref": "paper:paper-7a06f96aaed3"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Multisystem analysis of SCN1A R1648H knock-in mice showing ubiquitous interneuron hypoexcitability in thalamus, cortex, and hippocampus without changes in excitatory neurons.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}