Version history

{
  "scope": "mouse; V1, visual cortex, neocortex; Neuron",
  "claim_text": "This structured organization of inhibitory synaptic weights provides a circuit mechanism for tuned inhibition onto pyramidal cells despite dense connectivity, stabilizing activity within feature-spec…",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2023.12.013",
    "claim": "This structured organization of inhibitory synaptic weights provides a circuit mechanism for tuned inhibition onto pyramidal cells despite dense connectivity, stabilizing activity within feature-spec…",
    "cite_key": "Znamenskiy2024",
    "evidence": "In the neocortex, neural activity is shaped by the interaction of excitatory and inhibitory neurons, defined by the organization of their synaptic connections. Although connections among excitatory pyramidal neurons are sparse and functionally tuned, inhibitory connectivity is thought to be dense and largely unstructured. By measuring in vivo visual responses and synaptic connectivity of parvalbumin-expressing (PV+) inhibitory cells in mouse primary visual cortex, we show that the synaptic ...",
    "effect_size": "Among 138 cell pairs where we measured connectivity in both directions, we could detect post-synaptic potentials (PSPs) in both directions for 88 pairs (64%), only PV+ to Pyr inhibitory PSPs (IPSPs) for 21 pairs (15%), only Pyr to PV+ excitatory PSPs (EPSPs) for 12 pairs (9%), and no connections for 17 pairs (12%).",
    "text_access": "fulltext",
    "study_system": "mouse; V1, visual cortex, neocortex; Neuron",
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    "claim_source_sentence": "This structured organization of inhibitory synaptic weights provides a circuit mechanism for tuned inhibition onto pyramidal cells despite dense connectivity, stabilizing activity within feature-specific excitatory ensembles while supporting competition between them.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "claim_rewritten_from_source": true,
    "effect_size_source_sentence": "Among 138 cell pairs where we measured connectivity in both directions, we could detect post-synaptic potentials (PSPs) in both directions for 88 pairs (64%), only PV+ to Pyr inhibitory PSPs (IPSPs) for 21 pairs (15%), only Pyr to PV+ excitatory PSPs (EPSPs) for 12 pairs (9%), and no connections for 17 pairs (12%)."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "Among 138 cell pairs where we measured connectivity in both directions, we could detect post-synaptic potentials (PSPs) in both directions for 88 pairs (64%), only PV+ to Pyr inhibitory PSPs (IPSPs) for 21 pairs (15%), only Pyr to PV+ excitatory PSPs (EPSPs) for 12 pairs (9%), and no connections for 17 pairs (12%).",
  "review_repo": "ComputationalReviewRecurrence",
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  "source_span": "This structured organization of inhibitory synaptic weights provides a circuit mechanism for tuned inhibition onto pyramidal cells despite dense connectivity, stabilizing activity within feature-specific excitatory ensembles while supporting competition between them.",
  "study_system": "mouse; V1, visual cortex, neocortex; Neuron",
  "evidence_refs": [
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      "ref": "paper:paper-7ab8027f125a"
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  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "evidence_summary": "In the neocortex, neural activity is shaped by the interaction of excitatory and inhibitory neurons, defined by the organization of their synaptic connections. Although connections among excitatory pyramidal neurons are sparse and functionally tuned, inhibitory connectivity is thought to be dense and largely unstructured. By measuring in vivo visual responses and synaptic connectivity of parvalbumin-expressing (PV+) inhibitory cells in mouse primary visual cortex, we show that the synaptic ...",
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  "replication_status": "single_study",
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}