Version history

{
  "scope": "vip-interneurons",
  "claim_text": "Cholinergic input to V1 desynchronizes the cortex via SOM (not VIP) activation; optogenetic inhibition of VIP did not block desynchronization",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nn.4002",
    "pmid": "25915477",
    "tags": [
      "ach"
    ],
    "year": "2015",
    "claim": "Cholinergic input to V1 desynchronizes the cortex via SOM (not VIP) activation; optogenetic inhibition of VIP did not block desynchronization",
    "pmcid": "PMC4446146",
    "title": "An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity.",
    "journal": "",
    "citation": "Chen N, Sugihara H, Sur M.",
    "cite_key": "Chen2015a",
    "effect_size": null,
    "text_access": "fulltext",
    "citedByCount": 181,
    "isOpenAccess": "Y",
    "evidence_type": "mechanism",
    "linked_topics": [
      "ach"
    ],
    "_source_cluster": "cluster_07_in_vivo_function",
    "relevance_score": 0.7,
    "replication_status": null,
    "_source_cluster_index": 11,
    "claim_source_sentence": "Optogenetic inhibition of vasoactive intestinal peptide-expressing neurons did not block desynchronization, despite these neurons being activated at high levels of cholinergic drive."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-2c3589e2f07a"
  ],
  "source_span": "Optogenetic inhibition of vasoactive intestinal peptide-expressing neurons did not block desynchronization, despite these neurons being activated at high levels of cholinergic drive.",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-2c3589e2f07a"
    }
  ],
  "section_title": "In Vivo Function During Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": null,
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "unevaluated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}