Details

scope
mouse, cortex L2/3, two-photon calcium imaging during sleep
claim_text
PV interneuron calcium activity increases during slow-wave sleep while pyramidal cell mean activity decreases
section_id
section_08_evidence_package
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
effect_size
increased PV-In activity during SWS; decreased Pyr activity
review_repo
ComputationalReviewPV
section_ref
wiki_page:computationalreviewpv-08
source_kind
review_finding
source_path
evidence/section_08_evidence_package.json
source_span
Parvalbumin-positive inhibitory interneurons (PV-In) showed an increase in calcium activity during SWS episodes
study_system
mouse, cortex L2/3, two-photon calcium imaging during sleep
section_title
In Vivo Dynamics and Behavioural Correlates
evidence_summary
During SWS, PV-In activity increased while Pyr cells decreased; a subpopulation of Pyr cells was upregulated during spindles; REM sleep mediated general downregulation independent of PV inhibition
review_bundle_ref
analysis_bundle:ab-e6261c8263e7
replication_status
replication_unknown
review_package_ref
analysis_bundle:ab-e6261c8263e7
source_artifact_ref
wiki_page:computationalreviewpv-08
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
commit_sha
df9fc7e8d455b084152c9d713558dae0013cef21
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
raw_fields
{
  "n": 0,
  "doi": "10.1523/JNEUROSCI.1957-20.2021",
  "claim": "PV interneuron calcium activity increases during slow-wave sleep while pyramidal cell mean activity decreases",
  "evidence": "During SWS, PV-In activity increased while Pyr cells decreased; a subpopulation of Pyr cells was upregulated during spindles; REM sleep mediated general downregulation independent of PV inhibition",
  "effect_size": "increased PV-In activity during SWS; decreased Pyr activity",
  "text_access": "abstract_only",
  "study_system": "mouse, cortex L2/3, two-photon calcium imaging during sleep",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Parvalbumin-positive inhibitory interneurons (PV-In) showed an increase in calcium activity during SWS episodes",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Parvalbumin-positive inhibitory interneurons (PV-In) showed an increase in calcium activity during SWS episodes, while activity remained unchanged during REM sleep episodes"
}
source_refs
[
  "paper:paper-5b0ef670f97d"
]
evidence_refs
[
  {
    "ref": "paper:paper-5b0ef670f97d"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

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