Version history

{
  "scope": "Shank3-/- mouse thalamic reticular nucleus",
  "claim_text": "Shank3-deficient PV neurons of the TRN exhibit increased burst firing, decreased tonic firing, and reduced PV expression with lower calcium-buffering capacity",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.1202-25.2026",
    "claim": "Shank3-deficient PV neurons of the TRN exhibit increased burst firing, decreased tonic firing, and reduced PV expression with lower calcium-buffering capacity",
    "evidence": "Shank3-deficient PV neurons of the TRN exhibit increased burst firing, decreased tonic firing, and reduced PV expression with lower calcium-buffering capacity",
    "effect_size": "Pronounced increases in burst firing occurrence; decreased tonic firing frequency; faster dendritic calcium transient decay",
    "text_access": "abstract_only",
    "study_system": "Shank3-/- mouse thalamic reticular nucleus",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "TRN PV neurons of Shank3−/− mice exhibit pronounced increases in burst firing occurrence, decreased tonic firing frequency, and faster dendritic calcium transient decay. We pinpointed reduced PV expression as the culprit and used the added buffer approach to confirm the decrease in calcium-buffering capacity in mutant neurons.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "TRN PV neurons of Shank3-/- mice exhibit pronounced increases in burst firing occurrence, decreased tonic firing frequency, and faster dendritic calcium transient decay."
  },
  "section_id": "section_09_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json",
  "effect_size": "Pronounced increases in burst firing occurrence; decreased tonic firing frequency; faster dendritic calcium transient decay",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-09",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-1936bf669c0c"
  ],
  "source_span": "TRN PV neurons of Shank3−/− mice exhibit pronounced increases in burst firing occurrence, decreased tonic firing frequency, and faster dendritic calcium transient decay. We pinpointed reduced PV expression as the culprit and used the added buffer approach to confirm the decrease in calcium-buffering capacity in mutant neurons.",
  "study_system": "Shank3-/- mouse thalamic reticular nucleus",
  "evidence_refs": [
    {
      "ref": "paper:paper-1936bf669c0c"
    }
  ],
  "section_title": "Brain Region and Layer Context: Beyond Primary Sensory Cortex",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Shank3-deficient PV neurons of the TRN exhibit increased burst firing, decreased tonic firing, and reduced PV expression with lower calcium-buffering capacity",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-09",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}