Version history

{
  "scope": "Mouse motor cortex (M1), layer 5B; rabies-ChR2 + paired recordings",
  "claim_text": "In mouse motor cortex, corticostriatal-to-corticospinal excitatory connectivity is essentially unidirectional, defining a 'rectifying' hierarchical microcircuit among L5B output classes.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.4759-11.2012",
    "claim": "In mouse motor cortex, corticostriatal-to-corticospinal excitatory connectivity is essentially unidirectional, defining a 'rectifying' hierarchical microcircuit among L5B output classes.",
    "cite_key": "Kiritani2012",
    "evidence": "Optogenetic activation via retrograde rabies-ChR2 plus paired patch-clamp recordings of identified corticospinal and corticostriatal L5B neurons in mouse M1.",
    "effect_size": "Within-class recurrence higher among corticostriatal than corticospinal neurons; across-class connectivity essentially zero in the corticospinal-to-corticostriatal direction (qualitative).",
    "text_access": "abstract_only",
    "study_system": "Mouse motor cortex (M1), layer 5B; rabies-ChR2 + paired recordings",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "In contrast, across-class connectivity was extraordinarily asymmetric, essentially unidirectional from corticostriatal to corticospinal.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Both corticospinal and callosally projecting corticostriatal neurons in layer 5B formed within-class (recurrent) connections, with higher connection probability among corticostriatal than among corticospinal neurons."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "Within-class recurrence higher among corticostriatal than corticospinal neurons; across-class connectivity essentially zero in the corticospinal-to-corticostriatal direction (qualitative).",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-e1291622a820"
  ],
  "source_span": "In contrast, across-class connectivity was extraordinarily asymmetric, essentially unidirectional from corticostriatal to corticospinal.",
  "study_system": "Mouse motor cortex (M1), layer 5B; rabies-ChR2 + paired recordings",
  "evidence_refs": [
    {
      "ref": "paper:paper-e1291622a820"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Optogenetic activation via retrograde rabies-ChR2 plus paired patch-clamp recordings of identified corticospinal and corticostriatal L5B neurons in mouse M1.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}