microRNA Deficiency in VIP+ Interneurons Leads to Cortical Circuit Dysfunction.

Details

scope: cortex (mouse)
claim_text: microRNA Deficiency in VIP+ Interneurons Leads to Cortical Circuit Dysfunction.
section_id: section_06
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json
review_repo: ComputationalReviewVIP
section_ref: wiki_page:computationalreviewvip-06-synaptic-properties
source_kind: review_finding
source_path: evidence/section_06_evidence_package.json
source_span
study_system: cortex (mouse)
section_title: Synaptic Properties and Connectivity
review_bundle_ref: analysis_bundle:ab-2ce40c33e827
replication_status: single
review_package_ref: analysis_bundle:ab-2ce40c33e827
source_artifact_ref: wiki_page:computationalreviewvip-06-synaptic-properties
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json
commit_sha: 95e761177f7d2ec565983d3307c14ec238f9677c
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP

Raw fields (5)

raw_fields

{
  "n": "",
  "doi": "10.1093/cercor/bhz236",
  "claim": "microRNA Deficiency in VIP+ Interneurons Leads to Cortical Circuit Dysfunction.",
  "title": null,
  "cite_key": "Qiu2020",
  "evidence": "microRNA Deficiency in VIP+ Interneurons Leads to Cortical Circuit Dysfunction.. Genetically distinct GABAergic interneuron subtypes play diverse roles in cortical circuits. Previous studies revealed that microRNAs (miRNAs) are differentially expressed in cortical interneuron subtypes, and are essential for the normal migration, maturation, and survival of medial ganglionic eminence-derived interneuron subtypes. How miRNAs function in vasoactive intestinal peptide expressing (VIP+) interneurons derived from the caudal ganglionic eminence remains elusive.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "cortex (mouse)",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "single",
  "_source_cluster_index": 97,
  "claim_source_sentence": null,
  "replication_evidence_dois": []
}

source_refs

[
  "paper:paper-e09b4f7909d5"
]

evidence_refs

[
  {
    "ref": "paper:paper-e09b4f7909d5"
  }
]

source_policy

{
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

evidence_summary

microRNA Deficiency in VIP+ Interneurons Leads to Cortical Circuit Dysfunction.. Genetically distinct GABAergic interneuron subtypes play diverse roles in cortical circuits. Previous studies revealed that microRNAs (miRNAs) are differentially expressed in cortical interneuron subtypes, and are essential for the normal migration, maturation, and survival of medial ganglionic eminence-derived interneuron subtypes. How miRNAs function in vasoactive intestinal peptide expressing (VIP+) interneurons derived from the caudal ganglionic eminence remains elusive.

microRNA Deficiency in VIP+ Interneurons Leads to Cortical Circuit Dysfunction.

Details

Replication

Discussion