These findings provide a comprehensive molecular profile of DS PV interneurons,…

These findings provide a comprehensive molecular profile of DS PV interneurons, distinguishing them from other striatal PV populations, and reveal specific gene expression changes associated with psychostimulant exposure and reward-driven behaviors.

{
  "n": 0,
  "doi": "10.3389/fncel.2025.1648461",
  "claim": "These findings provide a comprehensive molecular profile of DS PV interneurons, distinguishing them from other striatal PV populations, and reveal specific gene expression changes associated with psychostimulant exposure and reward-driven behaviors.",
  "cite_key": "Naon2025",
  "evidence": "",
  "effect_size": "95%",
  "text_access": "fulltext",
  "study_system": "Using the Ribotag approach in <i>Pvalb-Cre</i> mice, we profiled the translatome of DS PV interneurons and identified over 2,700 transcripts significantly enriched (fold-change > 1.5) in this populati",
  "source_cluster_id": "cluster_04",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "We also compared the overlap between the genes we found to be enriched in the DS PV interneurons with those enriched in the PV interneurons of the nucleus accumbens (Acb) unveiled using the Pvalb-Sun1-GFP mouse line ( ).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "SPNs constitute approximately 95% of all striatal neurons ( ), the remaining 5% being interneurons that form a highly organized and hierarchical network, essential for efficient input processing and proper striatum function ( ; )."
}

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