Version history

{
  "scope": "human, 3T diffusion MRI tractography",
  "claim_text": "Diffusion tractography in 64 humans isolates reciprocal subcortical connections between cerebellar dentate→putamen via thalamus and subthalamic nucleus→cerebellar cortex via pontine nuclei, validating the bidirectional CB-BG circuitry.",
  "raw_fields": {
    "n": 64,
    "doi": "10.3389/fnagi.2023.1019239",
    "claim": "Diffusion tractography in 64 humans isolates reciprocal subcortical connections between cerebellar dentate→putamen via thalamus and subthalamic nucleus→cerebellar cortex via pontine nuclei, validating the bidirectional CB-BG circuitry.",
    "cite_key": "Radhakrishnan2023",
    "evidence": "3T diffusion-weighted imaging tractography in 64 healthy participants spanning a wide age range identified bidirectional cerebello–basal ganglia structural pathways consistent with prior macaque rabies tracing.",
    "effect_size": "N=64 subjects",
    "text_access": "fulltext",
    "study_system": "human, 3T diffusion MRI tractography",
    "source_cluster_id": "cluster_06",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Results Tractography analysis isolated connections from the dentate nucleus to the contralateral putamen via the thalamus, and reciprocal tracts from the subthalamic nucleus to the contralateral cerebellar cortex via the pontine nuclei.",
    "replication_evidence_dois": [
      "10.1073/pnas.1000496107",
      "10.1038/nn1544"
    ],
    "effect_size_source_sentence": "Methods In this study, we validated and expanded the previous findings of the structural connectivity within the cerebellum-basal ganglia subcortical network, in a larger dataset of 64 subjects, across different age ranges."
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json",
  "effect_size": "N=64 subjects",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-ce7dd380a7f6"
  ],
  "source_span": "Results Tractography analysis isolated connections from the dentate nucleus to the contralateral putamen via the thalamus, and reciprocal tracts from the subthalamic nucleus to the contralateral cerebellar cortex via the pontine nuclei.",
  "study_system": "human, 3T diffusion MRI tractography",
  "evidence_refs": [
    {
      "ref": "paper:paper-ce7dd380a7f6"
    }
  ],
  "section_title": "Parallel Loop Channels: Motor, Limbic, Associative, and Beyond the Classic Three",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "3T diffusion-weighted imaging tractography in 64 healthy participants spanning a wide age range identified bidirectional cerebello–basal ganglia structural pathways consistent with prior macaque rabies tracing.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}