Persistent preparatory activity in mouse frontal cortex during motor planning r…

Persistent preparatory activity in mouse frontal cortex during motor planning requires reciprocal cortico-cerebellar loop activity — silencing frontal cortex abolishes preparatory activity in fastigial nucleus, and transient fastigial perturbation disrupts subsequent correct responses, indicating that the cortical attractor representation is multi-areal, not locally generated.

{
  "n": 0,
  "doi": "10.1038/s41586-018-0633-x",
  "claim": "Persistent preparatory activity in mouse frontal cortex during motor planning requires reciprocal cortico-cerebellar loop activity — silencing frontal cortex abolishes preparatory activity in fastigial nucleus, and transient fastigial perturbation disrupts subsequent correct responses, indicating that the cortical attractor representation is multi-areal, not locally generated.",
  "cite_key": "Gao2018",
  "evidence": "Optogenetic loss-of-function in mouse ALM and cerebellar nuclei during a sensory-discrimination delayed-response task — direct experimental challenge to single-area local-attractor models of mouse cortex working memory.",
  "effect_size": "qualitative",
  "text_access": "abstract_only",
  "study_system": "mouse cortico-cerebellar loop (anterior lateral motor cortex ↔ fastigial nucleus via thalamus) during delayed-response task",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "The silencing of frontal cortex activity abolished preparatory activity in the cerebellar nuclei, and fastigial activity was necessary to maintain cortical preparatory activity.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/s41586-019-0919-7",
    "10.1016/j.celrep.2021.109090"
  ],
  "effect_size_source_sentence": null
}

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