The GPe→striatum projection arises primarily from Npas1-expressing (arkypallida…

The GPe→striatum projection arises primarily from Npas1-expressing (arkypallidal) neurons, contacts both direct- and indirect-pathway SPNs, and is strengthened in a chronic PD model — providing a maladaptive substrate for hypokinetic symptoms.

{
  "n": 0,
  "doi": "10.1523/jneurosci.1720-15.2016",
  "claim": "The GPe→striatum projection arises primarily from Npas1-expressing (arkypallidal) neurons, contacts both direct- and indirect-pathway SPNs, and is strengthened in a chronic PD model — providing a maladaptive substrate for hypokinetic symptoms.",
  "cite_key": "Glajch2016",
  "evidence": "",
  "effect_size": "GPe→SPN inputs originate from Npas1+ neurons; strengthened in PD model",
  "text_access": "abstract_only",
  "study_system": "mouse, monosynaptic tracing, optogenetic mapping, 6-OHDA PD model",
  "source_cluster_id": "cluster_04",
  "replication_status": "replicated",
  "claim_source_sentence": "Our results indicate that the GPe input to SPNs arises primarily from Npas1-expressing neurons and is strengthened in a chronic Parkinson's disease (PD) model.",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2012.04.027",
    "10.1523/jneurosci.4672-14.2015"
  ],
  "effect_size_source_sentence": "Our results indicate that the GPe input to SPNs arises primarily from Npas1-expressing neurons and is strengthened in a chronic Parkinson's disease (PD) model."
}

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