Version history

{
  "scope": "humans, randomized-pairs trial of bilateral STN/GPi DBS vs medical management for PD",
  "claim_text": "Randomized trial in 156 patients with advanced Parkinson's disease showed STN/GPi neurostimulation produced significantly greater improvements at 6 months in quality of life (PDQ-39 +9.5 points) and motor symptoms (UPDRS-III +19.6 points) than medical management.",
  "raw_fields": {
    "n": 156,
    "doi": "10.1056/nejmoa060281",
    "claim": "Randomized trial in 156 patients with advanced Parkinson's disease showed STN/GPi neurostimulation produced significantly greater improvements at 6 months in quality of life (PDQ-39 +9.5 points) and motor symptoms (UPDRS-III +19.6 points) than medical management.",
    "cite_key": "Deuschl2006",
    "evidence": "",
    "effect_size": "PDQ-39 mean Δ +9.5 points; UPDRS-III mean Δ +19.6 points; P<0.001",
    "text_access": "abstract_only",
    "study_system": "humans, randomized-pairs trial of bilateral STN/GPi DBS vs medical management for PD",
    "source_cluster_id": "cluster_04",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Pairwise comparisons showed that neurostimulation, as compared with medication alone, caused greater improvements from baseline to six months in the PDQ-39 (50 of 78 pairs, P=0.02) and the UPDRS-III (55 of 78, P<0.001), with mean improvements of 9.5 and 19.6 points, respectively.",
    "replication_evidence_dois": [
      "10.1056/nejmoa000827"
    ],
    "effect_size_source_sentence": "Pairwise comparisons showed that neurostimulation, as compared with medication alone, caused greater improvements from baseline to six months in the PDQ-39 (50 of 78 pairs, P=0.02) and the UPDRS-III (55 of 78, P<0.001), with mean improvements of 9.5 and 19.6 points, respectively."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "effect_size": "PDQ-39 mean Δ +9.5 points; UPDRS-III mean Δ +19.6 points; P<0.001",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-04",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:dfd3826d-d6d3-4889-921f-d6fa51b8e9b8"
  ],
  "source_span": "Pairwise comparisons showed that neurostimulation, as compared with medication alone, caused greater improvements from baseline to six months in the PDQ-39 (50 of 78 pairs, P=0.02) and the UPDRS-III (55 of 78, P<0.001), with mean improvements of 9.5 and 19.6 points, respectively.",
  "study_system": "humans, randomized-pairs trial of bilateral STN/GPi DBS vs medical management for PD",
  "evidence_refs": [
    {
      "ref": "paper:dfd3826d-d6d3-4889-921f-d6fa51b8e9b8"
    }
  ],
  "section_title": "Striatal Output Pathways: Direct, Indirect, and Beyond",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-04",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}