Lefort & Petersen 2017 — canonical mouse barrel multipatch dataset on layer-spe…

{
  "n": null,
  "doi": "10.1093/cercor/bhx094",
  "claim": "Lefort & Petersen 2017 — canonical mouse barrel multipatch dataset on layer-specific E→E STP. Layer 2 presynaptic = facilitation; other layers = depression. Direct support for cluster_02.",
  "cite_key": "Lefort2017",
  "evidence": "Neurons process information through spatiotemporal integration of synaptic input. Synaptic transmission between any given pair of neurons is typically a dynamic process with presynaptic action potentials (APs) evoking depressing or facilitating postsynaptic potentials when presynaptic APs occur within hundreds of milliseconds of each other. In order to understand neocortical function, it is therefore important to investigate such short-term synaptic plasticity at synapses between different types of neocortical neurons. Here, we examine short-term synaptic dynamics between excitatory neurons in different layers of the mouse C2 barrel column through in vitro whole-cell recordings. We find layer-dependent short-term plasticity, with depression being dominant at many synaptic connections. Interestingly, however, presynaptic layer 2 neurons predominantly give rise to facilitating excitatory synaptic output at short interspike intervals of 10 and 30 ms. Previous studies have found prominent burst firing of excitatory neurons in supragranular layers of awake mice. The facilitation we observed in the synaptic output of layer 2 may, therefore, be functionally relevant, possibly serving",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Layer-Dependent Short-Term Synaptic Plasticity Between Excitatory Neurons in the C2 Barrel Column of Mouse Primary Somatosensory Cortex.",
  "argument_role": "supporting",
  "replication_status": null,
  "claim_source_sentence": "In whole-cell paired recordings of excitatory neurons in different layers of the mouse C2 barrel column, layer-dependent short-term synaptic plasticity is observed, with depression dominant at many connections; however, presynaptic layer 2 neurons predominantly give rise to facilitating excitatory synaptic output at short inter-spike intervals of 10 and 30 ms.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-1f2e0ebd9f4c"
]

In whole-cell paired recordings of excitatory neurons in different layers of the mouse C2 barrel column, layer-dependent short-term synaptic plasticity is observed, with depression dominant at many connections; however, presynaptic layer 2 neurons predominantly give rise to facilitating excitatory synaptic output at short inter-spike intervals of 10 and 30 ms.

[
  {
    "ref": "paper:paper-1f2e0ebd9f4c"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

Neurons process information through spatiotemporal integration of synaptic input. Synaptic transmission between any given pair of neurons is typically a dynamic process with presynaptic action potentials (APs) evoking depressing or facilitating postsynaptic potentials when presynaptic APs occur within hundreds of milliseconds of each other. In order to understand neocortical function, it is therefore important to investigate such short-term synaptic plasticity at synapses between different types of neocortical neurons. Here, we examine short-term synaptic dynamics between excitatory neurons in different layers of the mouse C2 barrel column through in vitro whole-cell recordings. We find layer-dependent short-term plasticity, with depression being dominant at many synaptic connections. Interestingly, however, presynaptic layer 2 neurons predominantly give rise to facilitating excitatory synaptic output at short interspike intervals of 10 and 30 ms. Previous studies have found prominent burst firing of excitatory neurons in supragranular layers of awake mice. The facilitation we observed in the synaptic output of layer 2 may, therefore, be functionally relevant, possibly serving