Details
- scope
- Ppp1r2-Cre/NR1f/f transgenic mice
- claim_text
- Postnatal NMDA receptor ablation in 40-50% of cortical and hippocampal interneurons produces schizophrenia-like phenotypes after adolescence
- section_id
- section_11_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
- effect_size
- 40-50% of cortical and hippocampal interneurons had NR1 deleted; reduced GAD67 and PV expression
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-11
- source_kind
- review_finding
- source_path
- evidence/section_11_evidence_package.json
- source_span
- Here, we characterized a mouse strain in which the essential NR1 subunit of the NMDA receptor (NMDAR) was selectively eliminated in 40-50% of cortical and hippocampal interneurons in early postnatal development.
- study_system
- Ppp1r2-Cre/NR1f/f transgenic mice
- section_title
- Species Translation, Human Data, and Disease Models
- evidence_summary
- Mouse genetic model showing NMDAR deletion in interneurons produces behavioral abnormalities resembling schizophrenia
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-11
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/nn.2447", "claim": "Postnatal NMDA receptor ablation in 40-50% of cortical and hippocampal interneurons produces schizophrenia-like phenotypes after adolescence", "evidence": "Mouse genetic model showing NMDAR deletion in interneurons produces behavioral abnormalities resembling schizophrenia", "effect_size": "40-50% of cortical and hippocampal interneurons had NR1 deleted; reduced GAD67 and PV expression", "text_access": "fulltext", "study_system": "Ppp1r2-Cre/NR1f/f transgenic mice", "replication_status": "independently_replicated", "claim_source_sentence": "Here, we characterized a mouse strain in which the essential NR1 subunit of the NMDA receptor (NMDAR) was selectively eliminated in 40-50% of cortical and hippocampal interneurons in early postnatal development.", "replication_evidence_dois": [ "10.1093/schbul/sbs010", "10.1016/j.tins.2011.10.004" ], "effect_size_source_sentence": "Reduced expression of glutamic acid decarboxylase 67 and parvalbumin was accompanied by disinhibition of cortical excitatory neurons and reduced neuronal synchrony." }- source_refs
[ "paper:paper-31c511f98d76" ]
- evidence_refs
[ { "ref": "paper:paper-31c511f98d76" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }