Details
- scope
- human and mouse neocortical fast-spiking basket cells, computational model
- claim_text
- Human fast-spiking basket cells express abundant HCN1/HCN2 channels at the soma, accelerating membrane kinetics and EPSP-to-spike coupling compared to sparse HCN expression in rodent FS cells
- section_id
- section_12_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json
- effect_size
- HCN channels speed up human FS cell membrane kinetics to attain input-output rate close to rodent cells
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-12
- source_kind
- review_finding
- source_path
- evidence/section_12_evidence_package.json
- source_span
- Computational modeling demonstrated that HCN channel activity at the human fast-spiking cell soma membrane is sufficient to accelerate the input–output function as observed in cell recordings.
- study_system
- human and mouse neocortical fast-spiking basket cells, computational model
- section_title
- Computational Models of PV Circuit Function
- evidence_summary
- Electrophysiology, pharmacology, immunohistochemistry, and computational modeling comparing human and mouse FS basket cells
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-12
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1371/journal.pbio.3002001", "claim": "Human fast-spiking basket cells express abundant HCN1/HCN2 channels at the soma, accelerating membrane kinetics and EPSP-to-spike coupling compared to sparse HCN expression in rodent FS cells", "evidence": "Electrophysiology, pharmacology, immunohistochemistry, and computational modeling comparing human and mouse FS basket cells", "effect_size": "HCN channels speed up human FS cell membrane kinetics to attain input-output rate close to rodent cells", "text_access": "fulltext", "study_system": "human and mouse neocortical fast-spiking basket cells, computational model", "replication_status": "replication_unknown", "claim_source_sentence": "Computational modeling demonstrated that HCN channel activity at the human fast-spiking cell soma membrane is sufficient to accelerate the input–output function as observed in cell recordings.", "replication_evidence_dois": [], "effect_size_source_sentence": "HCN channels speed up human cell membrane potential kinetics and help attain an input–output rate close to that of rodent cells." }- source_refs
[ "paper:paper-8fdecf25a0b5" ]
- evidence_refs
[ { "ref": "paper:paper-8fdecf25a0b5" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }