Version history

{
  "scope": "mouse visual cortex, in vivo two-photon optogenetics",
  "claim_text": "VIP interneurons make local and transient holes in the inhibitory blanket extended by SOM cells via lateral disinhibition with an effective range of ~120 μm in lateral cortical space",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.3646-15.2016",
    "claim": "VIP interneurons make local and transient holes in the inhibitory blanket extended by SOM cells via lateral disinhibition with an effective range of ~120 μm in lateral cortical space",
    "evidence": "Two-photon optogenetic activation of individual VIP interneurons in mouse visual cortex in vivo with two-photon calcium imaging readout",
    "effect_size": "~120 μm effective range of VIP-mediated lateral disinhibition",
    "text_access": "abstract_only",
    "study_system": "mouse visual cortex, in vivo two-photon optogenetics",
    "replication_status": "single study",
    "claim_source_sentence": "VIP cells in vivo make local and transient 'holes' in the inhibitory blanket extended by SOM cells. By optogenetically activating single VIPs in live mice while recording the activity of nearby neurons, we find that VIPs break open a hole in blanket inhibition with an effective range of ~120 μm in lateral cortical space where excitatory activity can propagate.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "We find that VIPs break open a hole in blanket inhibition with an effective range of ~120 μm in lateral cortical space where excitatory activity can propagate."
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "effect_size": "~120 μm effective range of VIP-mediated lateral disinhibition",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-0a3cf7627c63"
  ],
  "source_span": "VIP cells in vivo make local and transient 'holes' in the inhibitory blanket extended by SOM cells. By optogenetically activating single VIPs in live mice while recording the activity of nearby neurons, we find that VIPs break open a hole in blanket inhibition with an effective range of ~120 μm in lateral cortical space where excitatory activity can propagate.",
  "study_system": "mouse visual cortex, in vivo two-photon optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-0a3cf7627c63"
    }
  ],
  "section_title": "Local Circuit Motifs: Perisomatic Inhibition, Feedback, and Feedforward",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Two-photon optogenetic activation of individual VIP interneurons in mouse visual cortex in vivo with two-photon calcium imaging readout",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "single study",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}