- raw_fields
{
"n": 0,
"doi": "10.1073/pnas.1411131111",
"claim": "Haploinsufficiency of Scn1a (Nav1.1) substantially reduces excitability in PV and SST interneurons while leaving pyramidal cells unaffected.",
"evidence": "",
"effect_size": "substantial reduction of excitability; increased threshold and rheobase",
"text_access": "fulltext",
"study_system": "Scn1a+/- mouse, layer V neocortex",
"replication_status": "independently_replicated",
"claim_source_sentence": "current-clamp recordings of intact interneurons in layer V of neocortical slices from mice with haploinsufficiency in Scn1a revealed substantial reduction of excitability in fast-spiking, parvalbumin-expressing interneurons and somatostatin-expressing interneurons",
"replication_evidence_dois": [
"10.1111/j.1528-1167.2011.03006.x",
"10.1523/JNEUROSCI.0193-18.2018"
],
"effect_size_source_sentence": "The threshold and rheobase for action potential generation were increased, the frequency of action potentials within trains was decreased, and action-potential firing within trains failed more frequently."
}- source_refs
[
"paper:paper-855d0bdbad3b"
]
- source_span
current-clamp recordings of intact interneurons in layer V of neocortical slices from mice with haploinsufficiency in Scn1a revealed substantial reduction of excitability in fast-spiking, parvalbumin-expressing interneurons and somatostatin-expressing interneurons
- evidence_refs
[
{
"ref": "paper:paper-855d0bdbad3b"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}