Version history

{
  "scope": "awake male mouse wS1 barrel cortex, eOPN3-mediated axonal silencing of wM1, wTLM and wS2 inputs; in vivo whole-cell and extracellular recordings",
  "claim_text": "In awake male mouse wS1 barrel cortex, axonal optogenetic silencing of inputs from whisker M1 (wM1) does not alter whisking-related spike rate or membrane-potential dynamics, whereas silencing thalamic (wTLM) and S2 (wS2) inputs strongly attenuates whisking-related supra- and sub-threshold dynamics — challenging the assumption that translaminar M1→S1 corticocortical feedback drives sensorimotor integration during spontaneous whisking.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.1148-23.2023",
    "claim": "In awake male mouse wS1 barrel cortex, axonal optogenetic silencing of inputs from whisker M1 (wM1) does not alter whisking-related spike rate or membrane-potential dynamics, whereas silencing thalamic (wTLM) and S2 (wS2) inputs strongly attenuates whisking-related supra- and sub-threshold dynamics — challenging the assumption that translaminar M1→S1 corticocortical feedback drives sensorimotor integration during spontaneous whisking.",
    "cite_key": "Kawatani2024",
    "evidence": "Awake male C57BL/6 mice; in vivo whole-cell and extracellular recording in wS1 during spontaneous whisking; selective axonal silencing using G-protein-coupled opsin eOPN3 of wM1, wTLM and wS2 inputs.",
    "effect_size": "wM1-axon silencing: no significant change; wTLM-axon silencing: marked decrease in modulation depth of whisking-phase-tuned neurons; wS2-axon silencing: large attenuation of subthreshold dynamics without affecting whisking-variable tuning.",
    "text_access": "fulltext",
    "study_system": "awake male mouse wS1 barrel cortex, eOPN3-mediated axonal silencing of wM1, wTLM and wS2 inputs; in vivo whole-cell and extracellular recordings",
    "argument_role": "supporting",
    "replication_status": "conflicting_with_prior",
    "claim_source_sentence": "Despite an extensive innervation, inhibition of inputs from the whisker primary motor cortex (wM1) to wS1 did not alter the spike rates and dynamics of wS1 neurons during whisking. In contrast, inhibition of axons from the whisker-related thalamus (wTLM) and the whisker secondary somatosensory cortex (wS2) to wS1 largely attenuated the whisking-related supra- and sub-threshold dynamics of wS1 neurons.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1101/2024.02.11.579810",
      "10.1016/j.neuron.2013.10.059"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "wM1-axon silencing: no significant change; wTLM-axon silencing: marked decrease in modulation depth of whisking-phase-tuned neurons; wS2-axon silencing: large attenuation of subthreshold dynamics without affecting whisking-variable tuning.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-940bf3abf181"
  ],
  "source_span": "Despite an extensive innervation, inhibition of inputs from the whisker primary motor cortex (wM1) to wS1 did not alter the spike rates and dynamics of wS1 neurons during whisking. In contrast, inhibition of axons from the whisker-related thalamus (wTLM) and the whisker secondary somatosensory cortex (wS2) to wS1 largely attenuated the whisking-related supra- and sub-threshold dynamics of wS1 neurons.",
  "study_system": "awake male mouse wS1 barrel cortex, eOPN3-mediated axonal silencing of wM1, wTLM and wS2 inputs; in vivo whole-cell and extracellular recordings",
  "evidence_refs": [
    {
      "ref": "paper:paper-940bf3abf181"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Awake male C57BL/6 mice; in vivo whole-cell and extracellular recording in wS1 during spontaneous whisking; selective axonal silencing using G-protein-coupled opsin eOPN3 of wM1, wTLM and wS2 inputs.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "conflicting_with_prior",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}