Version history

{
  "scope": "mouse visual, somatosensory and motor cortex; in vivo optogenetic activation of PV interneurons with extracellular recordings",
  "claim_text": "Mouse visual, somatosensory and motor cortex all show the paradoxical suppression of parvalbumin-interneuron firing in response to optogenetic PV excitation predicted by inhibition-stabilized network theory, indicating that strong recurrent excitation balanced by feedback inhibition is a common operating regime of mouse neocortex.",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.54875",
    "claim": "Mouse visual, somatosensory and motor cortex all show the paradoxical suppression of parvalbumin-interneuron firing in response to optogenetic PV excitation predicted by inhibition-stabilized network theory, indicating that strong recurrent excitation balanced by feedback inhibition is a common operating regime of mouse neocortex.",
    "cite_key": "Sanzeni2020",
    "evidence": "Simple two-population ISN models describe the data well and let us quantify coupling strength. We find ISN effects without sensory stimulation and even during light anesthesia. Average paradoxical effects result only with transgenic, not viral, opsin expression in parvalbumin (PV)-positive neurons; theory and expression data show this is consistent with ISN operation.",
    "effect_size": "",
    "text_access": "fulltext",
    "study_system": "mouse visual, somatosensory and motor cortex; in vivo optogenetic activation of PV interneurons with extracellular recordings",
    "argument_role": "supporting",
    "replication_status": "single_lab",
    "claim_source_sentence": "We find clear evidence for ISN operation in mouse visual, somatosensory, and motor cortex.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "effect_size": "",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-d6edd2b57842"
  ],
  "source_span": "We find clear evidence for ISN operation in mouse visual, somatosensory, and motor cortex.",
  "study_system": "mouse visual, somatosensory and motor cortex; in vivo optogenetic activation of PV interneurons with extracellular recordings",
  "evidence_refs": [
    {
      "ref": "paper:paper-d6edd2b57842"
    }
  ],
  "section_title": "10. Physiological signature II — persistent activity and attractor dynamics supported by E→E recurrence (delay-period activity in mouse PFC/ALM, working memory, head-direction)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Simple two-population ISN models describe the data well and let us quantify coupling strength. We find ISN effects without sensory stimulation and even during light anesthesia. Average paradoxical effects result only with transgenic, not viral, opsin expression in parvalbumin (PV)-positive neurons; theory and expression data show this is consistent with ISN operation.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_lab",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}