Chrna2+ layer-5 Martinotti cells (Mα2) in mouse primary motor cortex receive mo…

Chrna2+ layer-5 Martinotti cells (Mα2) in mouse primary motor cortex receive monosynaptic input from local pyramidal cells, local PV interneurons, and long-range inputs from motor thalamus, basal forebrain substantia innominata, and globus pallidus; transient overexcitation of Mα2 cells impairs sensorimotor integration (hanging-wire test) — defining a Martinotti subtype with distinct subcortical input integration not shared by other SST cells.

{
  "n": null,
  "doi": "10.1111/ejn.70086",
  "claim": "Chrna2+ layer-5 Martinotti cells (Mα2) in mouse primary motor cortex receive monosynaptic input from local pyramidal cells, local PV interneurons, and long-range inputs from motor thalamus, basal forebrain substantia innominata, and globus pallidus; transient overexcitation of Mα2 cells impairs sensorimotor integration (hanging-wire test) — defining a Martinotti subtype with distinct subcortical input integration not shared by other SST cells.",
  "title": null,
  "cite_key": "Velica2025",
  "evidence": "Chrna2-Cre × monosynaptic rabies tracing in mouse M1; chemogenetic overexcitation + behavioral assay (hanging-wire test).",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse M1 forelimb area; rabies tracing + chemogenetics",
  "target_section": "section_05",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 110,
  "claim_source_sentence": "We found direct input from pyramidal cells and local parvalbumin interneurons. In addition, we found long-range direct inputs from the motor thalamus, substantia innominata of the basal forebrain, and globus pallidus. Based on the observed input pattern, we tested and found an increased number of falls in the hanging wire test upon temporary overexcitation of Chrna2+ layer 5 Martinotti cells, suggesting that Chrna2+ Martinotti cells in the motor cortex can interfere with sensorimotor integration.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-71336866a6ea"
]

We found direct input from pyramidal cells and local parvalbumin interneurons. In addition, we found long-range direct inputs from the motor thalamus, substantia innominata of the basal forebrain, and globus pallidus. Based on the observed input pattern, we tested and found an increased number of falls in the hanging wire test upon temporary overexcitation of Chrna2+ layer 5 Martinotti cells, suggesting that Chrna2+...

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