LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength o…

Details

scope: Mouse neocortex; layer L2/3/L5; pyramidal cells
claim_text: LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5
section_id: section_06
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_06_evidence_package.json
effect_size: 3 neurons
review_repo: ComputationalReviewRecurrence
section_ref: wiki_page:computationalreviewrecurrence-06-connectomic-micons
source_kind: review_finding
source_path: evidence/section_06_evidence_package.json
source_span: Employing an optogenetic strategy combined with shRNA knockdown of LPHN3, we found that LPHN3 did not influence probability of release at synapses formed by L2/3 neurons onto L5 pyramidal cells.
study_system: Mouse neocortex; layer L2/3/L5; pyramidal cells
section_title: 6. Connectomic resolution — MICrONS mouse V1/HVA millimetre-scale EM volume; pyramidal-pyramidal wiring statistics derived from it; reconciliation with paired-recording estimates
evidence_summary: Abstract of Neural Dev 2014 paper (PMID 24739570); recovered via targeted mouse-cortex E→E PubMed query.
review_bundle_ref: analysis_bundle:ab-d9c479db9be9
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-d9c479db9be9
source_artifact_ref: wiki_page:computationalreviewrecurrence-06-connectomic-micons
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_06_evidence_package.json
commit_sha: 79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence

Raw fields (4)

raw_fields

{
  "n": "n_unknown",
  "doi": "10.1186/1749-8104-9-7",
  "claim": "LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5",
  "cite_key": "OSullivan2014",
  "evidence": "Abstract of Neural Dev 2014 paper (PMID 24739570); recovered via targeted mouse-cortex E→E PubMed query.",
  "effect_size": "3 neurons",
  "text_access": "abstract_only",
  "study_system": "Mouse neocortex; layer L2/3/L5; pyramidal cells",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Employing an optogenetic strategy combined with shRNA knockdown of LPHN3, we found that LPHN3 did not influence probability of release at synapses formed by L2/3 neurons onto L5 pyramidal cells.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Employing an optogenetic strategy combined with shRNA knockdown of LPHN3, we found that LPHN3 did not influence probability of release at synapses formed by L2/3 neurons onto L5 pyramidal cells."
}

source_refs

[
  "paper:paper-690c21e55584"
]

evidence_refs

[
  {
    "ref": "paper:paper-690c21e55584"
  }
]

source_policy

{
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  "notes": [
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LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength o…

Details

Replication

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