Version history

{
  "scope": "Mouse barrel cortex L6 paired patch-clamp with optogenetic activation of L6 CC neurons",
  "claim_text": "Within mouse barrel cortex L6, optogenetic activation of corticocortical (CC) L6 cells reliably evokes synaptic responses in 100% of CC neighbors (14/14 pairs), whereas only 57% of corticothalamic (CT) cells (8/14) respond, and CT responses are small and slow — establishing partial isolation of the two L6 excitatory networks.",
  "raw_fields": {
    "n": 14,
    "doi": "10.1016/j.celrep.2017.11.049",
    "claim": "Within mouse barrel cortex L6, optogenetic activation of corticocortical (CC) L6 cells reliably evokes synaptic responses in 100% of CC neighbors (14/14 pairs), whereas only 57% of corticothalamic (CT) cells (8/14) respond, and CT responses are small and slow — establishing partial isolation of the two L6 excitatory networks.",
    "cite_key": "Crandall2017",
    "evidence": "Paired whole-cell recordings combined with optogenetic activation of L6 CC neurons in Ntsr1-Cre mouse barrel cortex slices.",
    "effect_size": "CC pairs: 14/14 (100%) responsive; CT pairs: 8/14 (57%) responsive, small-slow responses.",
    "text_access": "fulltext",
    "study_system": "Mouse barrel cortex L6 paired patch-clamp with optogenetic activation of L6 CC neurons",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "In 14 pairs of CT-CC cells tested, we recorded reliable synaptic responses from all CC neurons (100%). By contrast, only 8 of the CT cells (57%) generated responses, and all of those were small and slow.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "In 14 pairs of CT-CC cells tested, we recorded reliable synaptic responses from all CC neurons (100%). By contrast, only 8 of the CT cells (57%) generated responses"
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "CC pairs: 14/14 (100%) responsive; CT pairs: 8/14 (57%) responsive, small-slow responses.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-78f81bfb11b4"
  ],
  "source_span": "In 14 pairs of CT-CC cells tested, we recorded reliable synaptic responses from all CC neurons (100%). By contrast, only 8 of the CT cells (57%) generated responses, and all of those were small and slow.",
  "study_system": "Mouse barrel cortex L6 paired patch-clamp with optogenetic activation of L6 CC neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-78f81bfb11b4"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Paired whole-cell recordings combined with optogenetic activation of L6 CC neurons in Ntsr1-Cre mouse barrel cortex slices.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}