Optogenetic modulation of inhibitory or excitatory neurons in mouse auditory co…

Optogenetic modulation of inhibitory or excitatory neurons in mouse auditory cortex produces heterogeneous, mouse-specific changes in tone-evoked population responses and in behavioral frequency-discrimination acuity (sometimes paradoxical, including reductions in excitatory firing when inhibition is suppressed); however, the resulting cortical response changes consistently predict the behavioral acuity change for each subject — coupling network-level cortical state to perceptual readout.

{
  "n": 0,
  "doi": "10.1523/jneurosci.2457-17.2017",
  "claim": "Optogenetic modulation of inhibitory or excitatory neurons in mouse auditory cortex produces heterogeneous, mouse-specific changes in tone-evoked population responses and in behavioral frequency-discrimination acuity (sometimes paradoxical, including reductions in excitatory firing when inhibition is suppressed); however, the resulting cortical response changes consistently predict the behavioral acuity change for each subject — coupling network-level cortical state to perceptual readout.",
  "cite_key": "Briguglio2018",
  "evidence": "Theoretical studies have predicted that suppression of inhibition in such excitatory-inhibitory networks can lead to either an increase or, paradoxically, a decrease in excitatory neuronal firing, with consequent effects on stimulus selectivity. We found that, indeed, the effects of optogenetic manipulation on stimulus selectivity and behavior varied in both magnitude and sign across subjects, possibly reflecting differences in circuitry or expression of optogenetic factors.",
  "effect_size": "",
  "text_access": "abstract_only",
  "study_system": "mouse auditory cortex; cell-type-specific optogenetic manipulation + simultaneous electrophysiology and behavioral frequency-discrimination",
  "argument_role": "supporting",
  "replication_status": "single_lab",
  "claim_source_sentence": "Changes in neural population responses consistently predicted behavioral changes for individuals separately, including improvement and impairment in acuity.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
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Theoretical studies have predicted that suppression of inhibition in such excitatory-inhibitory networks can lead to either an increase or, paradoxically, a decrease in excitatory neuronal firing, with consequent effects on stimulus selectivity. We found that, indeed, the effects of optogenetic manipulation on stimulus selectivity and behavior varied in both magnitude and sign across subjects, possibly reflecting differences in circuitry or expression of optogenetic factors.