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{
"n": "",
"doi": "10.1038/s41537-025-00638-6",
"claim": "Cell-type specific reductions in interneuron gene expression within the cingulate gyrus of schizophrenia and bipolar disorder subjects.",
"title": null,
"cite_key": "Krolewski2025",
"evidence": "Cell-type specific reductions in interneuron gene expression within the cingulate gyrus of schizophrenia and bipolar disorder subjects.. Schizophrenia (SZ) and bipolar disorder (BP) patients share overlapping neurocognitive deficits of varied magnitude. Neuroimaging in patients and postmortem gene expression analyses suggest that compromised cingulate gyrus GABA-ergic interneurons may contribute to cognitive impairments in SZ and BP. To address this, we used radioactive in situ hybridization to investigate potential gene expression signatures for SZ and BP using interneuron cell-type specific ",
"effect_size": null,
"text_access": "fulltext",
"study_system": "cortex/HC",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "single",
"_source_cluster_index": 175,
"claim_source_sentence": null,
"replication_evidence_dois": []
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"paper:paper-e7ec58a4ee73"
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Cell-type specific reductions in interneuron gene expression within the cingulate gyrus of schizophrenia and bipolar disorder subjects.. Schizophrenia (SZ) and bipolar disorder (BP) patients share overlapping neurocognitive deficits of varied magnitude. Neuroimaging in patients and postmortem gene expression analyses suggest that compromised cingulate gyrus GABA-ergic interneurons may contribute to cognitive impairments in SZ and BP. To address this, we used radioactive in situ hybridization to investigate potential gene expression signatures for SZ and BP using interneuron cell-type specific