The external globus pallidus comprises two distinct neuronal populations — prot…

The external globus pallidus comprises two distinct neuronal populations — prototypic GABAergic neurons (parvalbumin+, antiphase to STN, targeting downstream BG nuclei) and arkypallidal neurons (preproenkephalin+, in-phase with STN, projecting back to striatum) — establishing a fundamental dichotomy.

{
  "n": 79,
  "doi": "10.1016/j.neuron.2012.04.027",
  "claim": "The external globus pallidus comprises two distinct neuronal populations — prototypic GABAergic neurons (parvalbumin+, antiphase to STN, targeting downstream BG nuclei) and arkypallidal neurons (preproenkephalin+, in-phase with STN, projecting back to striatum) — establishing a fundamental dichotomy.",
  "cite_key": "Mallet2012",
  "evidence": "",
  "effect_size": "prototypic: PV+, antiphase to STN, target BG nuclei; arkypallidal: PPE+, in-phase with STN, target striatum",
  "text_access": "fulltext",
  "study_system": "parkinsonian rats, juxtacellular recording-labelling and immunocytochemistry of GPe",
  "source_cluster_id": "cluster_04",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Preproenkephalin mRNA + cells make up ∼40% of all GPe neurons ( Hoover and Marshall, 2002; Voorn et al., 1999 ), yet large-scale extracellular recordings with low-impedance multielectrode arrays show that GP-TA neurons constitute ∼20% of active GPe units ( Mallet et al., 2008a ).",
  "replication_evidence_dois": [
    "10.1523/jneurosci.4662-14.2015",
    "10.1523/jneurosci.4672-14.2015",
    "10.1016/j.neuron.2015.03.007",
    "10.1016/j.neuron.2015.12.017"
  ],
  "effect_size_source_sentence": "A first population of prototypic GABAergic GPe neurons fire antiphase to subthalamic nucleus (STN) neurons, often express parvalbumin, and target downstream basal ganglia nuclei, including STN."
}

[
  "paper:paper-40de7d59349c"
]

Preproenkephalin mRNA + cells make up ∼40% of all GPe neurons ( Hoover and Marshall, 2002; Voorn et al., 1999 ), yet large-scale extracellular recordings with low-impedance multielectrode arrays show that GP-TA neurons constitute ∼20% of active GPe units ( Mallet et al., 2008a ).

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