- claim_text
Whole-cell recordings of mouse V1 L2/3 neurons with optogenetic input-specific manipulation show that rapid (~100 ms) adaptation to brief stimuli is mediated by input-specific short-term synaptic depression of L4→L2/3 transmission — distinct from the mechanism reported for prolonged stimuli — enabling flexible control of sensory encoding across a wide range of time scales.
- raw_fields
{
"n": 0,
"doi": "10.1016/j.neuron.2023.07.003",
"claim": "Whole-cell recordings of mouse V1 L2/3 neurons with optogenetic input-specific manipulation show that rapid (~100 ms) adaptation to brief stimuli is mediated by input-specific short-term synaptic depression of L4→L2/3 transmission — distinct from the mechanism reported for prolonged stimuli — enabling flexible control of sensory encoding across a wide range of time scales.",
"cite_key": "Li2023b",
"evidence": "In-vivo whole-cell recording in mouse V1 L2/3 with measurement of synaptic currents during brief-stimulus adaptation plus optogenetic L4-specific manipulation.",
"effect_size": "qualitative — input-specific L4→L2/3 short-term depression mediates brief-stimulus rapid adaptation",
"text_access": "fulltext",
"study_system": "awake mouse V1 L2/3 pyramidal neurons during brief-stimulus adaptation",
"argument_role": "supporting",
"replication_status": "single_study",
"claim_source_sentence": "rapid adaptation is generated by stimulus-specific suppression of excitatory and inhibitory synaptic inputs. Targeted optogenetic experiments reveal that these synaptic effects are due to input-specific short-term depression of transmission between layers 4 and 2/3",
"source_provenance_status": "ok",
"replication_evidence_dois": [],
"effect_size_source_sentence": "input-specific short-term depression of transmission between layers 4 and 2/3"
}- source_refs
[
"paper:paper-6f5ed5bda0ea"
]
- source_span
rapid adaptation is generated by stimulus-specific suppression of excitatory and inhibitory synaptic inputs. Targeted optogenetic experiments reveal that these synaptic effects are due to input-specific short-term depression of transmission between layers 4 and 2/3
- evidence_refs
[
{
"ref": "paper:paper-6f5ed5bda0ea"
}
]- source_policy
{
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"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
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