- claim_text
Pathway-specific inhibition shows that mouse mediodorsal-thalamus → medial prefrontal cortex projection supports working-memory maintenance while mPFC → MD supports subsequent choice; delay-tuned mPFC neurons require MD input for sustained activity (absent on error trials), and enhancing MD excitability improves performance.
- raw_fields
{
"n": 0,
"doi": "10.1038/nn.4568",
"claim": "Pathway-specific inhibition shows that mouse mediodorsal-thalamus → medial prefrontal cortex projection supports working-memory maintenance while mPFC → MD supports subsequent choice; delay-tuned mPFC neurons require MD input for sustained activity (absent on error trials), and enhancing MD excitability improves performance.",
"cite_key": "Bolkan2017",
"evidence": "We further identify mPFC neurons that display elevated spiking during the delay, a feature that was absent on error trials and required MD inputs for sustained maintenance. Delay-tuned neurons had minimal overlap with spatially tuned neurons, and each mPFC population exhibited mutually exclusive dependence on MD and hippocampal inputs. We found that enhancing MD excitability was sufficient to enhance task performance.",
"effect_size": "",
"text_access": "fulltext",
"study_system": "mouse mediodorsal thalamus and medial prefrontal cortex; pathway-specific chemogenetic inhibition with electrophysiology during a delayed working-memory task",
"argument_role": "supporting",
"replication_status": "single_lab",
"claim_source_sentence": "Using pathway-specific inhibition, we found directional interactions between mouse MD and medial PFC (mPFC), with MD-to-mPFC supporting working memory maintenance and mPFC-to-MD supporting subsequent choice.",
"source_provenance_status": "ok",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-3ec6d1461090"
]
- evidence_refs
[
{
"ref": "paper:paper-3ec6d1461090"
}
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{
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"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}- evidence_summary
We further identify mPFC neurons that display elevated spiking during the delay, a feature that was absent on error trials and required MD inputs for sustained maintenance. Delay-tuned neurons had minimal overlap with spatially tuned neurons, and each mPFC population exhibited mutually exclusive dependence on MD and hippocampal inputs. We found that enhancing MD excitability was sufficient to enhance task performance.