Version history

{
  "scope": "mouse and human cortex (review)",
  "claim_text": "Schubert et al. (2024) summarized that mammalian cortex contains ~60 inhibitory transcriptomic types organized into PV, SST, VIP, and Lamp5/Sncg subclasses, with VIP cells primarily targeting other GABAergic subclasses (notably SST) to mediate disinhibition of local pyramidal neurons.",
  "raw_fields": {
    "n": null,
    "doi": "10.1007/s00424-024-02923-2",
    "claim": "Schubert et al. (2024) summarized that mammalian cortex contains ~60 inhibitory transcriptomic types organized into PV, SST, VIP, and Lamp5/Sncg subclasses, with VIP cells primarily targeting other GABAergic subclasses (notably SST) to mediate disinhibition of local pyramidal neurons.",
    "title": null,
    "cite_key": "Mao2024",
    "evidence": "Multimodal review consolidates current consensus: mouse cortex ~60 inhibitory t-types within 4 subclasses; VIP→SST→PYR disinhibitory motif is canonical; Pvalb-Vipr2 chandelier subtype noted within VIP nomenclature.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "mouse and human cortex (review)",
    "target_section": "section_02",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replicated",
    "_source_cluster_index": 32,
    "claim_source_sentence": "Inhibitory neurons were subdivided into parvalbumin (PV), somatostatin (SST), vasoactive intestinal polypeptide (VIP), and 'other (i.e. Lamp5/Sncg)' subpopulations, which altogether comprise ~60 t-types. The majority of VIP interneurons preferentially target other GABAergic subclasses, notably SST cells, consequently disinhibiting local pyramidal neurons."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-367b1305876d"
  ],
  "source_span": "Inhibitory neurons were subdivided into parvalbumin (PV), somatostatin (SST), vasoactive intestinal polypeptide (VIP), and 'other (i.e. Lamp5/Sncg)' subpopulations, which altogether comprise ~60 t-types. The majority of VIP interneurons preferentially target other GABAergic subclasses, notably SST cells, consequently disinhibiting local pyramidal neurons.",
  "study_system": "mouse and human cortex (review)",
  "evidence_refs": [
    {
      "ref": "paper:paper-367b1305876d"
    }
  ],
  "section_title": "Species Differences, Human Relevance, and Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Multimodal review consolidates current consensus: mouse cortex ~60 inhibitory t-types within 4 subclasses; VIP→SST→PYR disinhibitory motif is canonical; Pvalb-Vipr2 chandelier subtype noted within VIP nomenclature.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}