- claim_text
Delta opioid receptors (DORs) engage multiple intracellular signaling cascades to differentially modulate inhibitory transmission from PV vs SST vs CCK interneurons in mouse PFC—revealing that within a single GPCR class, signaling-pathway diversity is recruited cell-type-specifically across the canonical interneuron taxonomy.
- raw_fields
{
"n": null,
"doi": "10.1016/j.celrep.2025.115293",
"claim": "Delta opioid receptors (DORs) engage multiple intracellular signaling cascades to differentially modulate inhibitory transmission from PV vs SST vs CCK interneurons in mouse PFC—revealing that within a single GPCR class, signaling-pathway diversity is recruited cell-type-specifically across the canonical interneuron taxonomy.",
"title": null,
"cite_key": "Alexander2025",
"evidence": "Optogenetic + pharmacological dissection in mouse PFC; cell-type-specific recordings of PV/SST/CCK IN inhibition.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse PFC; opto + pharmacology",
"target_section": "section_05",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "replication_unknown",
"_source_cluster_index": 126,
"claim_source_sentence": "Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal cortex GABAergic transmission.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-10534f3fdac9"
]
- evidence_refs
[
{
"ref": "paper:paper-10534f3fdac9"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}