Details

scope
mouse ALM; dopaminergic-circuit recordings + optogenetic manipulation during directional licking
section_id
section_10
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json
effect_size
review_repo
ComputationalReviewRecurrence
section_ref
wiki_page:computationalreviewrecurrence-10-persistent-activity
source_kind
review_finding
source_path
evidence/section_10_evidence_package.json
source_span
Unilateral optogenetic manipulations of D1Rneurons or DA afferents affected lateral licking in a way consistent with their role in planning contralateral movements.
study_system
mouse ALM; dopaminergic-circuit recordings + optogenetic manipulation during directional licking
section_title
10. Physiological signature II — persistent activity and attractor dynamics supported by E→E recurrence (delay-period activity in mouse PFC/ALM, working memory, head-direction)
evidence_summary
review_bundle_ref
analysis_bundle:ab-d9c479db9be9
replication_status
single_lab
review_package_ref
analysis_bundle:ab-d9c479db9be9
source_artifact_ref
wiki_page:computationalreviewrecurrence-10-persistent-activity
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json
commit_sha
79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
claim_text
Cortical dopamine signals and D1-receptor neuron activity in mouse ALM track preparation and execution of directional licking with a contralateral bias, and unilateral optogenetic manipulation of D1R neurons or dopaminergic afferents biases lateral licking accordingly — placing dopaminergic modulation upstream of ALM preparatory dynamics.
raw_fields
{
  "n": 0,
  "doi": "10.1126/sciadv.adt2730",
  "claim": "Cortical dopamine signals and D1-receptor neuron activity in mouse ALM track preparation and execution of directional licking with a contralateral bias, and unilateral optogenetic manipulation of D1R neurons or dopaminergic afferents biases lateral licking accordingly — placing dopaminergic modulation upstream of ALM preparatory dynamics.",
  "cite_key": "Chen2025c",
  "evidence": "",
  "effect_size": "",
  "text_access": "abstract_only",
  "study_system": "mouse ALM; dopaminergic-circuit recordings + optogenetic manipulation during directional licking",
  "argument_role": "supporting",
  "replication_status": "single_lab",
  "claim_source_sentence": "Unilateral optogenetic manipulations of D1Rneurons or DA afferents affected lateral licking in a way consistent with their role in planning contralateral movements.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-7200a2f240a6"
]
evidence_refs
[
  {
    "ref": "paper:paper-7200a2f240a6"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

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