- claim_text
Channelrhodopsin-2-mediated photostimulation of as few as ~800 AGRP neurons in mice evoked voracious feeding within minutes, with intake scaling with photoexcitable neuron number, stimulation frequency and duration; POMC neuron stimulation reciprocally reduced intake — establishing AGRP and POMC arcuate populations as sufficient drivers of opposing feeding states.
- raw_fields
{
"n": null,
"doi": "10.1038/nn.2739",
"claim": "Channelrhodopsin-2-mediated photostimulation of as few as ~800 AGRP neurons in mice evoked voracious feeding within minutes, with intake scaling with photoexcitable neuron number, stimulation frequency and duration; POMC neuron stimulation reciprocally reduced intake — establishing AGRP and POMC arcuate populations as sufficient drivers of opposing feeding states.",
"cite_key": "Aponte2011",
"evidence": "fulltext_body",
"effect_size": null,
"text_access": "fulltext",
"study_system": null,
"source_cluster_id": "cluster_08",
"replication_status": "unreplicated",
"claim_source_sentence": "Two intermingled hypothalamic neuron populations specified by expression of agouti-related peptide (AGRP) or pro-opiomelanocortin (POMC) positively and negatively influence feeding behavior, respectively, possibly by reciprocally regulating downstream melanocortin receptors.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-c899e46ec4f7"
]
- source_span
Two intermingled hypothalamic neuron populations specified by expression of agouti-related peptide (AGRP) or pro-opiomelanocortin (POMC) positively and negatively influence feeding behavior, respectively, possibly by reciprocally regulating downstream melanocortin receptors.
- evidence_refs
[
{
"ref": "paper:paper-c899e46ec4f7"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}