Details

scope
neurodevelopmental disorders (review)
claim_text
Excitatory/inhibitory balance disruption through impaired PV interneuron function is a convergent mechanism in multiple neurodevelopmental disorders including autism, epilepsy, and schizophrenia.
section_id
section_05_evidence_package
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json
effect_size
PV interneuron dysfunction as convergent mechanism across ASD, epilepsy, schizophrenia
review_repo
ComputationalReviewPV
section_ref
wiki_page:computationalreviewpv-05
source_kind
review_finding
source_path
evidence/section_05_evidence_package.json
source_span
Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders.
study_system
neurodevelopmental disorders (review)
section_title
Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants
evidence_summary
Review establishing E/I imbalance as a common feature across multiple neurodevelopmental conditions, with PV interneuron dysfunction as a frequent contributor.
review_bundle_ref
analysis_bundle:ab-e6261c8263e7
replication_status
independently_replicated
review_package_ref
analysis_bundle:ab-e6261c8263e7
source_artifact_ref
wiki_page:computationalreviewpv-05
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json
commit_sha
df9fc7e8d455b084152c9d713558dae0013cef21
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
raw_fields
{
  "n": 0,
  "doi": "10.1016/j.neuron.2015.07.033",
  "claim": "Excitatory/inhibitory balance disruption through impaired PV interneuron function is a convergent mechanism in multiple neurodevelopmental disorders including autism, epilepsy, and schizophrenia.",
  "evidence": "Review establishing E/I imbalance as a common feature across multiple neurodevelopmental conditions, with PV interneuron dysfunction as a frequent contributor.",
  "effect_size": "PV interneuron dysfunction as convergent mechanism across ASD, epilepsy, schizophrenia",
  "text_access": "fulltext",
  "study_system": "neurodevelopmental disorders (review)",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders.",
  "replication_evidence_dois": [
    "10.1016/j.neuropharm.2011.01.022"
  ],
  "effect_size_source_sentence": "Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders."
}
source_refs
[
  "paper:paper-1c87abff01fe"
]
evidence_refs
[
  {
    "ref": "paper:paper-1c87abff01fe"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

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