Version history

{
  "scope": "Q8_GAD67",
  "claim_text": "Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia",
  "raw_fields": {
    "n": 15,
    "doi": "10.1523/jneurosci.23-15-06315.2003",
    "claim": "Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia",
    "evidence": "Study on PV interneuron alterations in schizophrenia",
    "effect_size": "Signal intensity for PV mRNA expression in PFC area 9 was significantly decreased in the subjects with schizophrenia, predominantly in layers III and IV",
    "text_access": "abstract_only",
    "study_system": "Q8_GAD67",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Markers of inhibitory neurotransmission are altered in the prefrontal cortex (PFC) of subjects with schizophrenia, and several lines of evidence suggest that these alterations may be most prominent in the subset of GABA-containing neurons that express the calcium-binding protein, parvalbumin (PV).",
    "replication_evidence_dois": [
      "10.1176/appi.ajp.2007.07081223",
      "10.1016/j.tins.2011.10.004"
    ],
    "effect_size_source_sentence": "Signal intensity for PV mRNA expression in PFC area 9 was significantly decreased in the subjects with schizophrenia, predominantly in layers III and IV."
  },
  "section_id": "section_11_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json",
  "effect_size": "Signal intensity for PV mRNA expression in PFC area 9 was significantly decreased in the subjects with schizophrenia, predominantly in layers III and IV",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-11",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-9febfa10db1a"
  ],
  "source_span": "Markers of inhibitory neurotransmission are altered in the prefrontal cortex (PFC) of subjects with schizophrenia, and several lines of evidence suggest that these alterations may be most prominent in the subset of GABA-containing neurons that express the calcium-binding protein, parvalbumin (PV).",
  "study_system": "Q8_GAD67",
  "evidence_refs": [
    {
      "ref": "paper:paper-9febfa10db1a"
    }
  ],
  "section_title": "Species Translation, Human Data, and Disease Models",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Study on PV interneuron alterations in schizophrenia",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}