In mouse V1 L2/3 pyramidal-pyramidal pairs, the broad two-orders-of-magnitude d…

In mouse V1 L2/3 pyramidal-pyramidal pairs, the broad two-orders-of-magnitude distribution of EPSP amplitudes is functionally organized: the few strong connections occur between neurons with the most correlated visual responses, while only weak connections link neurons with uncorrelated responses, and each neuron receives the majority of its local excitation from a small number of strong inputs sharing its feature tuning.

{
  "n": 0,
  "doi": "10.1038/nature14182",
  "claim": "In mouse V1 L2/3 pyramidal-pyramidal pairs, the broad two-orders-of-magnitude distribution of EPSP amplitudes is functionally organized: the few strong connections occur between neurons with the most correlated visual responses, while only weak connections link neurons with uncorrelated responses, and each neuron receives the majority of its local excitation from a small number of strong inputs sharing its feature tuning.",
  "cite_key": "Cossell2015",
  "evidence": "In-vivo two-photon calcium imaging of visual responses followed by ex-vivo multi-cell paired patch-clamp recording targeting imaged L2/3 pyramidal neurons in mouse V1.",
  "effect_size": "quantitative — strong-weak connection ratio organized by signal correlation; each neuron's local excitation dominated by a small number of strong like-tuned inputs",
  "text_access": "fulltext",
  "study_system": "adult mouse primary visual cortex (V1), layer 2/3 pyramidal pairs",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "the strength of connections between layer 2/3 (L2/3) pyramidal neurons in mouse primary visual cortex (V1) obeys a simple rule—the few strong connections occur between neurons with most correlated responses, while only weak connections link neurons with uncorrelated responses",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1038/nature11526",
    "10.1038/nature11539"
  ],
  "effect_size_source_sentence": "each neuron receives the majority of its local excitation from a small number of strong inputs provided by the few neurons with similar responses to visual features"
}

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the strength of connections between layer 2/3 (L2/3) pyramidal neurons in mouse primary visual cortex (V1) obeys a simple rule—the few strong connections occur between neurons with most correlated responses, while only weak connections link neurons with uncorrelated responses

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