Version history

{
  "scope": "mouse prelimbic PFC; opto + ephys, both sexes",
  "claim_text": "In mouse prelimbic PFC L2/3, opioid receptors regulate inhibitory transmission with cell-type and receptor-type specificity: DOR most strongly suppresses spontaneous IPSCs while MOR most strongly suppresses electrically-evoked GABA release; PV, SST, CCK, and VIP interneurons are differentially modulated by MOR vs DOR, and DOR acts via simultaneous pre- and postsynaptic mechanisms whereas MOR mechanisms vary across IN class.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.1963-24.2025",
    "claim": "In mouse prelimbic PFC L2/3, opioid receptors regulate inhibitory transmission with cell-type and receptor-type specificity: DOR most strongly suppresses spontaneous IPSCs while MOR most strongly suppresses electrically-evoked GABA release; PV, SST, CCK, and VIP interneurons are differentially modulated by MOR vs DOR, and DOR acts via simultaneous pre- and postsynaptic mechanisms whereas MOR mechanisms vary across IN class.",
    "title": null,
    "cite_key": "Cole2025",
    "evidence": "Whole-cell patch-clamp + optogenetics + viral cell-type targeting in male and female mouse prelimbic PFC.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse prelimbic PFC; opto + ephys, both sexes",
    "target_section": "section_05",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 117,
    "claim_source_sentence": "Cell type-specific optogenetics revealed that MOR and DOR differentially regulate inhibitory transmission from parvalbumin, somatostatin, cholecystokinin, and vasoactive intestinal peptide-expressing INs. Finally, we demonstrate that DOR regulates inhibitory transmission through simultaneous pre- and postsynaptic modifications to IN physiology, whereas MOR function varies between somato-dendritic or presynaptic signaling depending on cell type.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-02-classification",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-208bbf2a3ba6"
  ],
  "source_span": "Cell type-specific optogenetics revealed that MOR and DOR differentially regulate inhibitory transmission from parvalbumin, somatostatin, cholecystokinin, and vasoactive intestinal peptide-expressing INs. Finally, we demonstrate that DOR regulates inhibitory transmission through simultaneous pre- and postsynaptic modifications to IN physiology, whereas MOR function varies between somato-dendritic or presynaptic sign...",
  "study_system": "mouse prelimbic PFC; opto + ephys, both sexes",
  "evidence_refs": [
    {
      "ref": "paper:paper-208bbf2a3ba6"
    }
  ],
  "section_title": "Molecular Identity and Transcriptomic Taxonomy",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Whole-cell patch-clamp + optogenetics + viral cell-type targeting in male and female mouse prelimbic PFC.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-02-classification",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}