Version history

{
  "scope": "mouse cerebellar stellate cell interneurons",
  "claim_text": "Kv1 channels determine action potential repolarization at the spike initiation site but not at distal sites, while Kv3 channels control AP repolarization at presynaptic boutons, demonstrating functional segregation of axonal compartments by local Kv channel composition.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.4208-13.2014",
    "claim": "Kv1 channels determine action potential repolarization at the spike initiation site but not at distal sites, while Kv3 channels control AP repolarization at presynaptic boutons, demonstrating functional segregation of axonal compartments by local Kv channel composition.",
    "evidence": "Recordings in cerebellar stellate cell interneurons showing diverse Kv channel composition along axon allows compartment-specific AP control.",
    "effect_size": "Kv1 at AIS limits use-dependent spike broadening; Kv3 at boutons keeps APs brief",
    "text_access": "abstract_only",
    "study_system": "mouse cerebellar stellate cell interneurons",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Kv1 channels determine AP repolarization at the spike initiation site but not at more distal sites... Local control of AP repolarization at presynaptic boutons depends on Kv3 channels keeping APs brief, thus limiting Ca2+ influx and synaptic strength.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Kv1 channels determine AP repolarization at the spike initiation site but not at more distal sites, limiting the expression of use-dependent spike broadening to the most proximal axon region."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "Kv1 at AIS limits use-dependent spike broadening; Kv3 at boutons keeps APs brief",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-6fe34826161a"
  ],
  "source_span": "Kv1 channels determine AP repolarization at the spike initiation site but not at more distal sites... Local control of AP repolarization at presynaptic boutons depends on Kv3 channels keeping APs brief, thus limiting Ca2+ influx and synaptic strength.",
  "study_system": "mouse cerebellar stellate cell interneurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-6fe34826161a"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Recordings in cerebellar stellate cell interneurons showing diverse Kv channel composition along axon allows compartment-specific AP control.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}