Details
- scope
- Astrocyte-specific N-terminal mutant huntingtin transgenic mice
- claim_text
- Mutant huntingtin restricted to astrocytes reduces glutamate transporter expression and induces age-dependent neurological symptoms, supporting glial contribution to HD pathogenesis.
- section_id
- section_14
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-14
- source_kind
- review_finding
- source_path
- evidence/section_14_evidence_package.json
- study_system
- Astrocyte-specific N-terminal mutant huntingtin transgenic mice
- section_title
- Loop Dysfunction in Neurological and Psychiatric Disease
- evidence_summary
- Transgenic mice expressing N-terminal mutant huntingtin in astrocytes show body weight loss, motor deficits, reduced glutamate transporter, and earlier death.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-14
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
- raw_fields
{ "n": 0, "doi": "10.1073/pnas.0911503106", "claim": "Mutant huntingtin restricted to astrocytes reduces glutamate transporter expression and induces age-dependent neurological symptoms, supporting glial contribution to HD pathogenesis.", "cite_key": "Bradford2009", "evidence": "Transgenic mice expressing N-terminal mutant huntingtin in astrocytes show body weight loss, motor deficits, reduced glutamate transporter, and earlier death.", "effect_size": null, "text_access": "fulltext", "study_system": "Astrocyte-specific N-terminal mutant huntingtin transgenic mice", "source_cluster_id": "cluster_13", "replication_status": "independently_replicated", "claim_source_sentence": "Using primers that specifically amplify transgenic human htt\ntranscript, we found that the transcription level of htt-160Q is\nlower than in htt-23Q and N171-82Q mouse brains, as well as\nlower than in HD KI mouse brains, which express mutant htt at\nthe endogenous level (Fig. 1D).", "replication_evidence_dois": [ "10.3389/fnut.2026.1774416", "10.1186/s40478-025-02054-4" ], "effect_size_source_sentence": "Tydlacka S, Wang CE, Wang X, Li S, Li XJ (2008) Differential activities of the ubiquitin-\nproteasome system in neurons versus glia may account for the preferential accumu-\nlation of misfolded proteins in neurons." }- source_refs
[ "paper:paper-15958cf77777" ]
- source_span
Using primers that specifically amplify transgenic human htt transcript, we found that the transcription level of htt-160Q is lower than in htt-23Q and N171-82Q mouse brains, as well as lower than in HD KI mouse brains, which express mutant htt at the endogenous level (Fig. 1D).
- evidence_refs
[ { "ref": "paper:paper-15958cf77777" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }