- claim_text
Using a well-established condition-suppression model of tinnitus, we measured tinnitus-related changes in the microcircuits of excitatory/inhibitory neurons onto layer 5 pyramidal neurons (PNs), as well as changes in the excitability of vasoactive intestinal peptide (VIP) neurons in primary auditory cortex (A1).
- raw_fields
{
"n": null,
"doi": "10.1113/jp284675",
"year": "2023",
"claim": "Using a well-established condition-suppression model of tinnitus, we measured tinnitus-related changes in the microcircuits of excitatory/inhibitory neurons onto layer 5 pyramidal neurons (PNs), as well as changes in the excitability of vasoactive intestinal peptide (VIP) neurons in primary auditory cortex (A1).",
"title": null,
"journal": "The Journal of physiology",
"cite_key": "Ghimire2023a",
"evidence": "Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour",
"effect_size": "20% of",
"text_access": "abstract_only",
"study_system": "rat ACx/S1",
"_source_cluster": "cluster_06_disinhibition_circuit",
"snowball_origin": "forward_r2",
"replication_status": "replication_unknown",
"_source_cluster_index": 105,
"claim_source_sentence": "Using a well-established condition-suppression model of tinnitus, we measured tinnitus-related changes in the microcircuits of excitatory/inhibitory neurons onto layer 5 pyramidal neurons (PNs), as well as changes in the excitability of vasoactive intestinal peptide (VIP) neurons in primary auditory cortex (A1).",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Tinnitus affects roughly 15%-20% of the population while severely impacting 10% of those afflicted."
}- source_refs
[
"paper:paper-0dcf711aad7b"
]
- source_span
Using a well-established condition-suppression model of tinnitus, we measured tinnitus-related changes in the microcircuits of excitatory/inhibitory neurons onto layer 5 pyramidal neurons (PNs), as well as changes in the excitability of vasoactive intestinal peptide (VIP) neurons in primary auditory cortex (A1).
- evidence_refs
[
{
"ref": "paper:paper-0dcf711aad7b"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}