Version history

{
  "scope": "mouse PFC; opto + pharmacology",
  "claim_text": "Delta opioid receptors (DORs) engage multiple intracellular signaling cascades to differentially modulate inhibitory transmission from PV vs SST vs CCK interneurons in mouse PFC—revealing that within a single GPCR class, signaling-pathway diversity is recruited cell-type-specifically across the canonical interneuron taxonomy.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.celrep.2025.115293",
    "claim": "Delta opioid receptors (DORs) engage multiple intracellular signaling cascades to differentially modulate inhibitory transmission from PV vs SST vs CCK interneurons in mouse PFC—revealing that within a single GPCR class, signaling-pathway diversity is recruited cell-type-specifically across the canonical interneuron taxonomy.",
    "title": null,
    "cite_key": "Alexander2025",
    "evidence": "Optogenetic + pharmacological dissection in mouse PFC; cell-type-specific recordings of PV/SST/CCK IN inhibition.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse PFC; opto + pharmacology",
    "target_section": "section_05",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 126,
    "claim_source_sentence": "Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal cortex GABAergic transmission.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-10534f3fdac9"
  ],
  "source_span": "Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal cortex GABAergic transmission.",
  "study_system": "mouse PFC; opto + pharmacology",
  "evidence_refs": [
    {
      "ref": "paper:paper-10534f3fdac9"
    }
  ],
  "section_title": "Species Differences, Human Relevance, and Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Optogenetic + pharmacological dissection in mouse PFC; cell-type-specific recordings of PV/SST/CCK IN inhibition.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}