Version history

{
  "scope": "mammal PFC/frontal cortex/hippocampus",
  "claim_text": "To characterize the molecular identity of these LRG neurons, we injected a retrograde tracer (Alexa 594-tagged CTb) in dHPC and performed immunohistochemistry in prefrontal sections ( Figures S1 C and S1D). dHPC-projecting PFC LRG neurons include parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP)-expressing subpopulations, as well as small percentages of calretinin (CR) and neuropeptide-Y (NPY) expressing neurons ( Figures S1 E and S1F).",
  "raw_fields": {
    "n": 8,
    "doi": "10.1016/j.cell.2022.04.001",
    "year": "2022",
    "claim": "To characterize the molecular identity of these LRG neurons, we injected a retrograde tracer (Alexa 594-tagged CTb) in dHPC and performed immunohistochemistry in prefrontal sections ( Figures S1 C and S1D). dHPC-projecting PFC LRG neurons include parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP)-expressing subpopulations, as well as small percentages of calretinin (CR) and neuropeptide-Y (NPY) expressing neurons ( Figures S1 E and S1F).",
    "title": null,
    "journal": "Cell",
    "cite_key": "Malik2022",
    "evidence": "Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition",
    "effect_size": null,
    "text_access": "fulltext",
    "first_author": "Malik",
    "study_system": "mammal PFC/frontal cortex/hippocampus",
    "_source_cluster": "cluster_06_disinhibition_circuit",
    "author_list_short": "Malik, Li, Schamiloglu",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 33,
    "claim_source_sentence": "To characterize the molecular identity of these LRG neurons, we injected a retrograde tracer (Alexa 594-tagged CTb) in dHPC and performed immunohistochemistry in prefrontal sections ( Figures S1 C and S1D). dHPC-projecting PFC LRG neurons include parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP)-expressing subpopulations, as well as small percentages of calretinin (CR) and neuropeptide-Y (NPY) expressing neurons ( Figures S1 E and S1F).",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Open circles represent data from individual neurons (n = 8) and bars represent averages; one-way ANOVA followed by Tukey’s multiple comparison test, ∗∗∗ p < 0.001. (E) Schematic of the intersectional strategy to label dHPC-projecting PFC LRG neurons. (F) Representative images showing ChR2-eYFP-expressing, dHPC-projecting PFC LRG neurons."
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_07_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-07-disinhibition-framework",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-f83cd6e11b6c"
  ],
  "source_span": "To characterize the molecular identity of these LRG neurons, we injected a retrograde tracer (Alexa 594-tagged CTb) in dHPC and performed immunohistochemistry in prefrontal sections ( Figures S1 C and S1D). dHPC-projecting PFC LRG neurons include parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP)-expressing subpopulations, as well as small percentages of calretinin (CR) and neuropeptid...",
  "study_system": "mammal PFC/frontal cortex/hippocampus",
  "evidence_refs": [
    {
      "ref": "paper:paper-f83cd6e11b6c"
    }
  ],
  "section_title": "Local Circuit Motifs and the Disinhibition Framework",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-07-disinhibition-framework",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_07_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}