Syngap1 haploinsufficiency restricted to MGE-derived interneurons increases PV+…

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scope: mouse auditory cortex, Syngap1 haploinsufficiency
claim_text: Syngap1 haploinsufficiency restricted to MGE-derived interneurons increases PV+ neuron firing threshold, decreases excitatory synaptic drive, and impairs thalamocortical AMPA component
section_id: section_04_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_04_evidence_package.json
effect_size: Increased firing threshold, decreased excitatory synaptic drive in PV neurons
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-04
source_kind: review_finding
source_path: evidence/section_04_evidence_package.json
source_span: Syngap1 haploinsufficiency significantly affected the intrinsic properties, overall leading to increased firing threshold, and decreased excitatory synaptic drive of Parvalbumin (PV)+ neurons in adult Layer IV A1.
study_system: mouse auditory cortex, Syngap1 haploinsufficiency
section_title: Morphological Diversity: Basket Cells, Chandelier Cells, and Beyond
evidence_summary: Syngap1 haploinsufficiency restricted to MGE-derived interneurons increases PV+ neuron firing threshold, decreases excitatory synaptic drive, and impairs thalamocortical AMPA component
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-04
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_04_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": null,
  "doi": "10.7554/elife.97100",
  "claim": "Syngap1 haploinsufficiency restricted to MGE-derived interneurons increases PV+ neuron firing threshold, decreases excitatory synaptic drive, and impairs thalamocortical AMPA component",
  "evidence": "Syngap1 haploinsufficiency restricted to MGE-derived interneurons increases PV+ neuron firing threshold, decreases excitatory synaptic drive, and impairs thalamocortical AMPA component",
  "effect_size": "Increased firing threshold, decreased excitatory synaptic drive in PV neurons",
  "text_access": "abstract_only",
  "study_system": "mouse auditory cortex, Syngap1 haploinsufficiency",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Syngap1 haploinsufficiency significantly affected the intrinsic properties, overall leading to increased firing threshold, and decreased excitatory synaptic drive of Parvalbumin (PV)+ neurons in adult Layer IV A1.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Syngap1 haploinsufficiency significantly affected the intrinsic properties, overall leading to increased firing threshold."
}

source_refs

[
  "paper:41e3ffd9-f0ba-49ca-875f-11724b72cd8d"
]

evidence_refs

[
  {
    "ref": "paper:41e3ffd9-f0ba-49ca-875f-11724b72cd8d"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

Syngap1 haploinsufficiency restricted to MGE-derived interneurons increases PV+…

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