Version history

{
  "scope": "mouse medial prefrontal cortex; in vivo calcium imaging across postnatal development plus optogenetic perturbation and spiking-network modeling",
  "claim_text": "In mouse medial prefrontal cortex during the first two postnatal weeks, neural activity decorrelates following specific spatial patterns and the excitation/inhibition ratio simultaneously tilts toward inhibition; optogenetic manipulation and network modeling show these two phenomena are mechanistically linked — a developmental rise in inhibition causally drives the decorrelation of mPFC activity, a precondition for the sparse, decorrelated state on which attractor and persistent-activity computations are typically founded.",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.78811",
    "claim": "In mouse medial prefrontal cortex during the first two postnatal weeks, neural activity decorrelates following specific spatial patterns and the excitation/inhibition ratio simultaneously tilts toward inhibition; optogenetic manipulation and network modeling show these two phenomena are mechanistically linked — a developmental rise in inhibition causally drives the decorrelation of mPFC activity, a precondition for the sparse, decorrelated state on which attractor and persistent-activity computations are typically founded.",
    "cite_key": "Chini2022",
    "evidence": "Throughout development, the brain transits from early highly synchronous activity patterns to a mature state with sparse and decorrelated neural activity. In the mouse medial prefrontal cortex (mPFC), neural activity during the first two postnatal weeks decorrelates following specific spatial patterns. This process is accompanied by a concomitant tilting of excitation-inhibition (E-I) ratio toward inhibition.",
    "effect_size": "",
    "text_access": "abstract_only",
    "study_system": "mouse medial prefrontal cortex; in vivo calcium imaging across postnatal development plus optogenetic perturbation and spiking-network modeling",
    "argument_role": "supporting",
    "replication_status": "single_lab",
    "claim_source_sentence": "Using optogenetic manipulations and neural network modeling, we show that the two phenomena are mechanistically linked, and that a relative increase of inhibition drives the decorrelation of neural activity.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "effect_size": "",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-c0dd57304483"
  ],
  "source_span": "Using optogenetic manipulations and neural network modeling, we show that the two phenomena are mechanistically linked, and that a relative increase of inhibition drives the decorrelation of neural activity.",
  "study_system": "mouse medial prefrontal cortex; in vivo calcium imaging across postnatal development plus optogenetic perturbation and spiking-network modeling",
  "evidence_refs": [
    {
      "ref": "paper:paper-c0dd57304483"
    }
  ],
  "section_title": "10. Physiological signature II — persistent activity and attractor dynamics supported by E→E recurrence (delay-period activity in mouse PFC/ALM, working memory, head-direction)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Throughout development, the brain transits from early highly synchronous activity patterns to a mature state with sparse and decorrelated neural activity. In the mouse medial prefrontal cortex (mPFC), neural activity during the first two postnatal weeks decorrelates following specific spatial patterns. This process is accompanied by a concomitant tilting of excitation-inhibition (E-I) ratio toward inhibition.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_lab",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}