Version history

{
  "scope": "mouse retrosplenial cortex (RSC), awake head-fixed, cell-type-specific 2p + optogenetics",
  "claim_text": "Two-photon Ca²⁺ imaging combined with cell-type-specific optogenetics in awake mouse retrosplenial cortex shows that thalamocortical excitatory input to RSC is reduced 1–2 s before hippocampal sharp-wave ripples, indicating a cell-type-specific, transient drop in long-range E drive that precedes SWR events.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.celrep.2022.111132",
    "claim": "Two-photon Ca²⁺ imaging combined with cell-type-specific optogenetics in awake mouse retrosplenial cortex shows that thalamocortical excitatory input to RSC is reduced 1–2 s before hippocampal sharp-wave ripples, indicating a cell-type-specific, transient drop in long-range E drive that precedes SWR events.",
    "cite_key": "Chambers2022",
    "evidence": "Patch-clamp + 2p Ca²⁺ imaging + cell-type-specific optogenetics in awake head-fixed mouse retrosplenial cortex.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse retrosplenial cortex (RSC), awake head-fixed, cell-type-specific 2p + optogenetics",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "However, using cell-type-specific two-photon Caimaging and optogenetics, we show that, 1-2 s before SWRs, superficial inhibition and thalamocortical input in RSC is reduced.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_01",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_01_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-01-introduction",
  "source_kind": "review_finding",
  "source_path": "evidence/section_01_evidence_package.json",
  "source_refs": [
    "paper:paper-c1444c10be66"
  ],
  "source_span": "However, using cell-type-specific two-photon Caimaging and optogenetics, we show that, 1-2 s before SWRs, superficial inhibition and thalamocortical input in RSC is reduced.",
  "study_system": "mouse retrosplenial cortex (RSC), awake head-fixed, cell-type-specific 2p + optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-c1444c10be66"
    }
  ],
  "section_title": "1. Introduction — what \"excitatory recurrence\" means operationally in mouse cortex, and why isolating it from inhibition and from clinical framings is a defensible analytic move for basic-research synthesis",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Patch-clamp + 2p Ca²⁺ imaging + cell-type-specific optogenetics in awake head-fixed mouse retrosplenial cortex.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-01-introduction",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_01_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}