ErbB4 is expressed by parvalbumin-expressing chandelier and basket cells where…

Details

scope: mouse neocortex and hippocampus
claim_text: ErbB4 is expressed by parvalbumin-expressing chandelier and basket cells where it promotes formation of axo-axonic inhibitory synapses via Nrg1 signaling
section_id: section_06_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-06
source_kind: review_finding
source_path: evidence/section_06_evidence_package.json
source_span: ErbB4 is expressed by many parvalbumin-expressing chandelier and basket cells, where it localizes to axon terminals and postsynaptic densities receiving glutamatergic input.
study_system: mouse neocortex and hippocampus
section_title: Synaptic Physiology: Input Specificity, Output Targeting, and Short-Term Dynamics
evidence_summary: Gain- and loss-of-function experiments demonstrated ErbB4 cell-autonomously promotes axo-axonic synapse formation over pyramidal cells, mediated by Nrg1
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: independently_replicated
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-06
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1038/nature08928",
  "claim": "ErbB4 is expressed by parvalbumin-expressing chandelier and basket cells where it promotes formation of axo-axonic inhibitory synapses via Nrg1 signaling",
  "evidence": "Gain- and loss-of-function experiments demonstrated ErbB4 cell-autonomously promotes axo-axonic synapse formation over pyramidal cells, mediated by Nrg1",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse neocortex and hippocampus",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "ErbB4 is expressed by many parvalbumin-expressing chandelier and basket cells, where it localizes to axon terminals and postsynaptic densities receiving glutamatergic input.",
  "replication_evidence_dois": [
    "10.1126/sciadv.adv0588",
    "10.1038/s41467-025-68059-8"
  ],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:7913334d-871d-4c98-b6ee-6187bd1f77b0"
]

evidence_refs

[
  {
    "ref": "paper:7913334d-871d-4c98-b6ee-6187bd1f77b0"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

ErbB4 is expressed by parvalbumin-expressing chandelier and basket cells where…

Details

Replication

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