The mediodorsal thalamus sustains rule representations in mouse PFC by amplifyi…

{
  "n": 114,
  "doi": "10.1038/nature22073",
  "claim": "The mediodorsal thalamus sustains rule representations in mouse PFC by amplifying local PFC functional connectivity rather than relaying categorical information.",
  "cite_key": "Schmitt2017",
  "evidence": "Optogenetic perturbations and large-scale recordings during a rule-guided attention task in mice.",
  "effect_size": "kHz) noise was presented for 100 ms to signal task rule (rule 1 [",
  "text_access": "fulltext",
  "study_system": "mouse mediodorsal thalamus / mPFC (rule-guided attention task)",
  "source_cluster_id": "cluster_05",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Here, by investigating prefrontal cortical (PFC) representation of two rules used to guide attention, we find that the mediodorsal thalamus (MD) sustains these representations without relaying categorical information.",
  "replication_evidence_dois": [
    "10.1038/nn.4568",
    "10.1038/nature15398",
    "10.1038/nature22324"
  ],
  "effect_size_source_sentence": "Subsequently, either high-pass (11 kHz) or low-pass (10 kHz) noise was presented for 100 ms to signal task rule (rule 1 [high-pass]: attend to vision; rule 2 [low-pass]: attend to audition), and following a brief delay where head position was stably maintanined, the animal selected between spatially conflicting visual and auditory stimuli to receive a reward."
}

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]

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