Details
- scope
- postmortem human prefrontal cortex, schizophrenia
- claim_text
- PVBC inhibition is decreased in schizophrenia to compensate for upstream pyramid cell excitation deficit; this re-balances E/I but at insufficient level for gamma oscillation power required for cognitive control
- section_id
- section_10_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
- effect_size
- Gamma oscillation power insufficient for high levels of cognitive control
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-10
- source_kind
- review_finding
- source_path
- evidence/section_10_evidence_package.json
- source_span
- These findings suggest a new model of cortical dysfunction in schizophrenia in which PVBC inhibition is decreased to compensate for an upstream deficit in pyramidal cell excitation.
- study_system
- postmortem human prefrontal cortex, schizophrenia
- section_title
- Oscillations and Network Dynamics: Gamma, Ripples, and Synchrony
- evidence_summary
- PVBC inhibition is decreased in schizophrenia to compensate for upstream pyramid cell excitation deficit; this re-balances E/I but at insufficient level for gamma oscillation power required for cognitive control
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-10
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1016/j.tins.2011.10.004", "claim": "PVBC inhibition is decreased in schizophrenia to compensate for upstream pyramid cell excitation deficit; this re-balances E/I but at insufficient level for gamma oscillation power required for cognitive control", "evidence": "PVBC inhibition is decreased in schizophrenia to compensate for upstream pyramid cell excitation deficit; this re-balances E/I but at insufficient level for gamma oscillation power required for cognitive control", "effect_size": "Gamma oscillation power insufficient for high levels of cognitive control", "text_access": "fulltext", "study_system": "postmortem human prefrontal cortex, schizophrenia", "replication_status": "replication_unknown", "claim_source_sentence": "These findings suggest a new model of cortical dysfunction in schizophrenia in which PVBC inhibition is decreased to compensate for an upstream deficit in pyramidal cell excitation.", "replication_evidence_dois": [], "effect_size_source_sentence": "This compensation is thought to re-balance cortical excitation and inhibition, but at a level insufficient to generate the gamma oscillation power required for high levels of cognitive control." }- source_refs
[ "paper:paper-6d36973b50ab" ]
- evidence_refs
[ { "ref": "paper:paper-6d36973b50ab" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }