Version history

{
  "scope": "mouse cortex multi-marker IHC",
  "claim_text": "Quantitative double-immunolabeling across mouse cortex established that parvalbumin, somatostatin, and VIP identify three reliably non-overlapping inhibitory subpopulations, while CR and NPY overlap substantially with SST (~21.6% and ~7.1% of SST+ cells respectively) — formalizing the canonical PV/SST/VIP partition in mouse but flagging marker promiscuity for CR.",
  "raw_fields": {
    "n": null,
    "doi": "10.1002/cne.22229",
    "claim": "Quantitative double-immunolabeling across mouse cortex established that parvalbumin, somatostatin, and VIP identify three reliably non-overlapping inhibitory subpopulations, while CR and NPY overlap substantially with SST (~21.6% and ~7.1% of SST+ cells respectively) — formalizing the canonical PV/SST/VIP partition in mouse but flagging marker promiscuity for CR.",
    "title": null,
    "cite_key": "Xu2010a",
    "evidence": "Double immunochemistry across mouse cortical regions; quantification of marker overlap across PV, SST, VIP, CR, NPY, CCK.",
    "effect_size": "SOM/CR overlap 21.6%; SOM/NPY 7.1%",
    "text_access": "abstract_only",
    "study_system": "mouse cortex multi-marker IHC",
    "target_section": "section_03",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "single_study",
    "_source_cluster_index": 60,
    "claim_source_sentence": "We found that, PV, SOM, and vasointenstinal peptide (VIP) reliably identify three nonoverlapping distinct subpopulations, as there was no overlap of immunoreactivity between PV and all the other chemical markers tested, and SOM and VIP did not show any overlap in labeled neurons in all the cortical areas."
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json",
  "effect_size": "SOM/CR overlap 21.6%; SOM/NPY 7.1%",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-02-classification",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-f74768c3fc02"
  ],
  "source_span": "We found that, PV, SOM, and vasointenstinal peptide (VIP) reliably identify three nonoverlapping distinct subpopulations, as there was no overlap of immunoreactivity between PV and all the other chemical markers tested, and SOM and VIP did not show any overlap in labeled neurons in all the cortical areas.",
  "study_system": "mouse cortex multi-marker IHC",
  "evidence_refs": [
    {
      "ref": "paper:paper-f74768c3fc02"
    }
  ],
  "section_title": "Molecular Identity and Transcriptomic Taxonomy",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Double immunochemistry across mouse cortical regions; quantification of marker overlap across PV, SST, VIP, CR, NPY, CCK.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-02-classification",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}