Version history

{
  "scope": "Human and mouse L1 neocortex Patch-seq",
  "claim_text": "Patch-seq recordings from human neurosurgical tissue identify four L1 transcriptomic subclasses with mouse homologs alongside types unmatched in mouse L1, demonstrating that mouse L1 interneuron taxonomy does not fully recapitulate human L1 diversity.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1126/science.adf0805",
    "claim": "Patch-seq recordings from human neurosurgical tissue identify four L1 transcriptomic subclasses with mouse homologs alongside types unmatched in mouse L1, demonstrating that mouse L1 interneuron taxonomy does not fully recapitulate human L1 diversity.",
    "cite_key": "Chartrand2023",
    "evidence": "Documents a methodological limit of mouse-only cell-type frameworks for understanding human cortical circuits — relevant to cluster_14 'cross-species' bracketing discussion.",
    "effect_size": "Four L1 transcriptomic subclasses with mouse homologs identified in human",
    "text_access": "abstract_only",
    "study_system": "Human and mouse L1 neocortex Patch-seq",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "Using Patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologs, along with distinct subtypes and types unmatched in mouse L1.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Using Patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologs, along with distinct subtypes and types unmatched in mouse L1."
  },
  "section_id": "section_16",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "effect_size": "Four L1 transcriptomic subclasses with mouse homologs identified in human",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "source_kind": "review_finding",
  "source_path": "evidence/section_16_evidence_package.json",
  "source_refs": [
    "paper:paper-86dac47be132"
  ],
  "source_span": "Using Patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologs, along with distinct subtypes and types unmatched in mouse L1.",
  "study_system": "Human and mouse L1 neocortex Patch-seq",
  "evidence_refs": [
    {
      "ref": "paper:paper-86dac47be132"
    }
  ],
  "section_title": "16. Synthesis — which computational claims the mouse-cortex E→E empirical record actually supports, where the bottleneck observations are, and what an inhibition-free, single-species, basic-research analytic framing misses",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Documents a methodological limit of mouse-only cell-type frameworks for understanding human cortical circuits — relevant to cluster_14 'cross-species' bracketing discussion.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}